2030 and beyond, Europe and the world will face opportunities and challenges of growth and sustainability of tremendous magnitude; to pro-actively tackle issues of green deal efficiency, digital inclusion and assurance of health and safety in a post pandemic world will be key. A powerful vision is needed to connect physical, digital, and human worlds, firmly anchored in future wireless technology and architectural research. The Hexa-X vision calls for an x-enabler fabric of connected intelligence, networks of networks, sustainability, global service coverage, extreme experience, and trustworthiness. Wireless technologies are of critical relevance for our society and economy today; their importance for growth will continue to steadily increase with 5G and its evolution, enabling new ecosystems and services motivated by strongly growing traffic and trillions of devices. The Hexa-X project ambition includes to develop key technology enablers in the areas of (i) fundamentally new radio access technologies at high frequencies and high-resolution localization and sensing; (ii) connected intelligence though AI-driven air interface and governance for future networks, and (iii) 6G architectural enablers for network disaggregation and dynamic dependability. Europe has been a leader in wireless network technologies for decades. It is now critical to unleash our best brains in the joint research ambition of a “flagship” project to maintain the global industry leadership for the B5G/6G era. The Hexa-X flagship is a unique effort of vision, and an opportunity for disruptive impact in sustainable growth and technology experience in Europe and worldwide!