Within the framework of a sustainable development in the industrial sector of processing and in particular that of chemistry, this project proposes the development of a miniaturized microwave reactor allowing a safe implementation of any fast chemical reactions at high temperature. Due to its specific design, the system will allow a rapid thermal dynamics due to the microwave heating which is suitable to the energy saving. This system will be tried on a family of chemical reactions concerning the synthesis of quinoline derivatives, molecules of industrial interest in pharmaceutics. Skraup’s reaction will so be implemented in applying some of the principles of green chemistry such as the use of glycerol, the elimination of toxic products… This project requires a multidisciplinary approach involving complementary research groups specialized in the following domains : chemical engineering, microwaves, organic chemistry and materials.