Liquid handling is actually a key operation in many laboratories, public or private, for research or education, in a broad spectrum of important fields such as Biology or Chemistry. Among liquid handling instruments, the micropipette is today a must-have in laboratory, with performances largely sustained by the interactions between the liquid and the consumable of the device, namely the tip made in polymer. The modulation of these liquid-polymer interactions is possible by acting on the surface chemistry and / or the physical characteristics of the solid surface at the microscale. In this context, the Institute of Chemistry of Clermont-Ferrand (ICCF - UMR 6296) via its "Inorganic Materials" team and the SME GILSON SAS wish to put their respective expertise to the development of new innovative solutions for liquid handling. Based on an already established collaboration that has allowed to identify promising research routes, the joint laboratory INOMALIS will develop a panel of innovations with variable TRL, allowing both to target its future sustainability through short time to market research axes, while developing new strategic research pathways, contrasting with contender solutions : A first axis will aim to implement innovative solutions to avoid the loss of samples during erroneous or delicate manipulations with a micropipette. This issue is of a huge interest in sampling situations with high value liquids (such as in certain areas of biology or in forensic science, for example). Based on surface treatment strategies by controlled fluorination, chemically modified polymer components will allow to efficiently confine the liquid, while maintaining its integral distribution. Others research axes will focus on modifying the liquid-polymer interactions of conical surfaces by approaches aiming to control the microtexturation of the polymer or to modulate finely the chemical functionnalization at the polymer surface. The objectives of the labcom INOMALIS will thus be to feed both the scientific knowledge in the field of innovative surface treatments on polymers with complex geometries and their interaction with a liquid of variable nature, while extending the potentialities of using a laboratory micropipette for liquid handling, with the opportunity to impact other devices where the dynamic interaction between a liquid and a polymer is critical.