Collaboration 4.0 project is a contribution to the main industry of the future challenge of the efficient place of humans in the factory of the future. Industry of the future means the high-tech digitalization of production systems to get more flexibility of the whole value chain to achieve personalized products and sustainability. Enabling technologies like Internet Of Things, wearables, robotics, Artificial Intelligence and 3D Printings are the key drivers of this industrial transformation. The main challenge is to keep the economic value of mass production (3.0) when competitive lot-size 1 personalized production (4.0). The Collaboration 4.0 project aims at studying working situations enabled by the new digital technologies in 4.0 industrial environment for their productivity and attractive features. The project addresses the Nb 3 ANR research axis “Fostering industrial renewal” and especially the Nb 1sub-axis “Factory of the future: Human, organization and technologies”. Its overarching objective is to design collaborative workplaces of the future in which workers and machines are closely combined to reach new sustainable performance in 4.0 industrial environment. The project is featured from three fundamental research hypotheses: 1) The Human-Machine collaborative activity of the future will be carried out in a new enabling competence-based industrial environment, 2) Digital technologies are flexible and frequently evolve, 3) Work and industrial organization highly influences the well performing Human-Machine collaborative activity. The project aims at designing new workplaces in which workers and machines share the same space to complete shared tasks by using work-enabling digital technologies. The worker will manage work activities controlling the machine tasks and instructing it. The machine is designed to meet the worker needs. It could provide worker with new ways of working. We want to define and characterize the new types of 4.0 collaborative workplaces useful and well performing in a specific industrial situation. The core issues are the efficient technology uses while producing and the industrial organization to be set up. Concretely, the project will study two different work situations from two case studies: a collaborative activity between a robot and a human on one side and between an augmented reality wearable and a human on the other side. Delivered results will be a classification of human-Machine collaborative work situations in an enabling industrial environment, a framework for analyzing an enabling collaborative industrial activity and recommendations for designing enabling industrial workplaces. The project is a multidisciplinary project combining industrial engineering, ergonomics and digital technologies. It is featured in five scientific tasks and one management task. A workplace-of-the-future demonstrator will be developed at the Grenoble INP S.MART technological platform from existing facilities. An industrial advisory board accompany the research partners to operationalize the theoretical propositions. It is a 48-month project and relies on two PhD thesis and an engineer position. The project will be managed by G-SCOP laboratory (industrial engineering, augmented reality) alongside with LIG (robotics and HMI) and ACTé (ergonomics). Each laboratory will bring to the project their human resources and equipment as necessary. Project results will be spread through scientific publications, guidelines for industrial companies and communication activities.