This practice-based research engages with Uruguay’s ongoing deinstitutionalisation process bringing together spatial theories of coexistence and participatory art. It draws on critical human geography to chart deinstitutionalisation as a social and spatial process, with the understanding that the departure from the psychiatric asylum must be negotiated well beyond its walls. This project combines techniques from contemporary documentary filmmaking and pedagogies of Latin American Third Cinema to experiment with audio-visual practice as a device for witnessing difference and reimagining life together within difference. This research will promote encounters between people, between disciplines, and between practice and theory, engaging in transformative community-processes and the public discussion of topical issues. It will operate micro-politically, employing artistic practice to bring into conversation service users, professionals and staff of Uruguay’s mental health system, carers and relatives, and other members of society. By enabling dialogues outside traditional settings and roles and extending the conversations on mental health beyond the bounds of disciplinary discourses and established institutions, this research will contribute to the understanding of mental health in the context of mad studies and critical disability studies, and will advance the dialogical potential of audio-visual practice and its development as a research method. Recent legislation in Uruguay set the deadline for closing all psychiatric asylums by 2025. However, the recurrent employment of confinement in Uruguay means that this occasion could introduce radical changes in mental health care or merely produce new ways of institutionalisation. Considering the deinstitutionalisation process through the lens of coexistence, I will identify the multiple spatialities and temporalities of confinement in contemporary Uruguay and explore the embodied practices that contest confinement and nurture plural coexistence. I will use audio-visual practice, combining documentary filmmaking and post-screening discussions to bring into conversation service users, carers, professionals and staff of Uruguay’s mental health system, and other members of society. By engaging in public discussion promoting encounters between people, between disciplines, and between practice and theory, this research will contribute to a critical understanding of mental health in contemporary Uruguay and will advance the development of audio-visual practice as a research method.