This research will create a map of patient symptoms, diseases, patient care and use of medicines and outcomes in GPs and hospitals, with particular attention to people with multiple long-term conditions. This map will researchers, doctors and policy makers to understand and improve how medicines are used, aiming to maximise the benefit for patients while reducing any harms from those medicines. Results from this research will be used to improve guidelines for patient care and to customise medicines to individual patients to improve their treatment. The programme will have a major focus on health and race inequalities, where multiple long-term conditions and care involving multiple medications are more common. This will pioneer new ways to improve patient care across the UK and internationally.