Bringing together health related data and enabling researchers to improve people’s lives will require teamwork with experts across the UK. As it stands, the amount of variation in where and how health related information is stored is a significant obstacle to this game changing research. The Alliance has been active since 2019, bringing together NHS data holders, Universities, charities and industrial partners to identify common challenges and work together to enable better use of data. In the next five years Alliance membership will be extended to non data custodians and complementary groups, including Trade Assocations. Alliance members play a central role in informing HDR UK’s activities in both building and improving the foundations to support health data research, enabling researchers to work in trustworthy ways across organisations and sources of health data, enabling research that has been impossible until now.