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Current prevention and treatment of obesity and type 2 diabetes (T2D) include energy-restricted diets and increased levels of physical activity, but adherence to such strategies is difficult, and maintenance is challenging for most individuals. Timing of food intake and fasting periods affect the circadian rhythms of metabolic organs (i.e. 'chrono-nutrition'), and experimental data from animal studies suggest promising effects of time-restricted eating on weight loss, glucose regulation, appetite and energy levels. Therefore, it is hypothesized that time-restricted eating, allowing dietary intake within a limited time interval during the day, will be an attractive, feasible and sustainable option for management of obesity and dysglycaemia. To understand the underlying mechanisms for potential health effects, research at Steno Diabetes Centre Copenhagen (SDCC) aims to examine the effects of time-restricted eating on both metabolic and behavioural parameters in adults with overweight and obesity at high risk of developing T2D. Chrono-nutrition is an emerging special interest within nutritional science and a crucial gap in the literature is to examine the interaction between exercise and meal timing on energy balance, and appetite and metabolic control in adults with obesity and T2D. By integrating my expertise in the biopsychology of appetite and energy balance with clinical approaches in T2D prevention, there is potential for synergistic impact on understanding and improving health. If this proposal is successful, the complementary training I will acquire at SDCC will address this gap in knowledge and expertise. With this Award I will gain experience with clinical populations (i.e. individuals with (pre)diabetes) and in more complex physiological assessment of glucose regulation and metabolism. I will expand my skillset and be better trained to conduct multidisciplinary, mechanistic nutritional research across a range of populations addressing overlapping themes pertaining to appetite control, physical activity and chrono-nutrition. I am at the career stage where I am seeking to catalyse my progression to an independent researcher and to obtain funding for a longer, larger fellowship award. This Travelling Skills Award is the ideal next step in my career as it will support me in acquiring knowledge and skills in a new discipline in order to address important questions in the field of nutrition.
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