Single cell RNA sequencing to dissect transcriptional variation in persistent malaria infections
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Malaria parasites can persist for several months without causing symptoms, infecting mosquitoes and presenting a roadblock to transmission reduction. In in vitro studies, Plasmodium has been observed to increase its investment in parasite multiplication and transmission in the presence of competing strains and other factors affecting its chances of survival. These strategies may be controlled epigenetically and remain to be examined during natural infections. The aim of the proposed project is to bring together genetic, immunologic and microscopy-based assays with a state-of-the-art transcriptomic analysis pipeline to investigate Plasmodium falciparum persistence, virulence, and adaptation over the course of single infections.
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