Antisocial behaviour poses a major burden for society. Revealing its causes may provide clues for treatment and prevention. However, antisocial behaviour is phenotypically heterogeneous and of polygenic nature, both of which seriously hamper current etiological investigations. The proposed research aims to tackle these two issues by using an innovative, integrated strategy incorporatinggenetics and imaging, and by capitalizing on the availability of large genetically informative datasets for antisocial behaviour as well as a smaller but unique dataset of juvenile delinquents with imaging data. We aim to identify biological pathways underlying antisocial behaviour, which could inform and improve current treatment strategies.