The goal of the CETOCOEN Excellence project of the Teamig Phase II is to establish the European Centre of Excellence in Environmental Health Sciences. In order to achieve that, Masaryk University in Brno, Czech Republic, teams up with the leading European research institutions including University College London, Swiss Federal Institute of Technology in Zurich, Biobanking and Biomolecular Resources Research Infrastructure, and International Clinical Research Centre at St. Anne’s Hospital. Building on existing expertise and proven track record of the existing RECETOX Centre at Masaryk university, the Teaming project partners developed a joint vision and a strategy for establishment of the interdisciplinary institute of the next generation. This project utilizes previous investments of the European Structural and Investment Funds to development of excellent research infrastructures and introduces strategic partnerships, advanced research management and research support functions, and new financial schemes needed to become one of the leading European research institutes. This allows the Centre to open the innovative research avenues towards improved understanding of the role of environmental factors in human health and aging, and innovative approaches to environmental and health protection in Europe.