PANDEM-2 implements and demonstrates the most important novel concepts and IT systems to improve the capacity of European pandemic planning and response. Following the PANDEM project (with the same coordinator and many shared partners) and extensive subsequent stakeholder engagement, research and prioritisation, PANDEM-2 meets the real-world needs of public health agencies responsible for pandemics (‘pandemic managers’) and first responders across Europe. PANDEM-2 will enable and demonstrate the capture and integration of pandemic-relevant data from international systems (Go.Data outputs, EWRS, TESSy, etc.), participative surveillance (Influenzanet, Studybugs, etc.), fron laboratory (next generation sequencing) systems and from social media (Twitter, Reddit). This data will be accessible and can be analysed via an online dashboard, designed and built to support the specific needs of pandemic managers. Additional high-priority tools for pandemic spread prediction, visual analytics and resources management, including workforce capacity mapping, will improve preparedness and planning, and enable pandemic managers to be as well positioned as possible for a pandemic when it comes. In order to test the system, while also networking and building relationships across borders and organisations, pandemic managers and first responders from multiple Member States will work together in EU-wise demonstrations, planning and responding to several pandemic scenarios, from Ebola to SARS/MERS CoV, to pandemic influenza. Pandemic communications, highlighted as a key capability gap, will be addressed by resource creation, training and evaluation.