The AXIS consortium is set up to enhance integration of an array of research disciplines connected to climate research around the common goal to enhance the assessment of potential impacts of climate change on the bio-physical systems and human society. To this end AXIS plans to launch and implement a single transnational call – funded by 11 European research funders. Through an open process AXIS has developed three topics for this call. Each topic is intended to enhance collaboration across typical community borders: between different sectoral views of climate impacts as well as between bio-physical climate impacts and socio-economic effects. For all topics stakeholder engagement is given a high relevance in the call, thus representing another dimension of interaction across boundaries: interaction of the science community with end-users (stakeholders) of the created knowledge (transdisciplinarity). The three anticipated research areas (topics) are: (1) Cross-sectoral and cross-scale climate change impact assessments; (2) Integration of biophysical climate change impacts estimates with economic models; (3) Developing pathways to achieve the long-term objectives of the Paris Agreement, taking into account interactions with SDGs closely linked to SDG 13 (“climate action”). The AXIS consortium is deeply embedded in JPI Climate and aims to implement elements of its Strategic Research & Innovation Agenda. JPI Climate and the ERA-NET promoting Climate Services ERA4CS include a number of additional activities. Therefore within this proposal no addition activities are planned. Close partnership of the AXIS consortium and JPI Climate with other key international initiatives (Belmont Forum, GFCS, Future Earth, UN PROVIA, Copernicus) will be sought in order to continue to work against fragmentation of disciplines and geographies in climate science. In this respect a close connection with the parallel CSA proposal SINCERE is planned.