Nanotechnology has been identified as a key enabling technology of economic growth and the value of nanomaterials in the global market is forecast to grow to €2 trillion by 2015. In order to be a market leader in this area, it is imperative that Europe invest in research where the gap between knowledge creation and successful commercialisation is bridged, and in training the next generation of highly skilled researchers in nanotechnology. This ETN will increase innovation capacity and strengthen doctoral training in nanotechnology on a European level. The ETN will push research into applications at the cutting-edge of nanotechnology by uniting leading experts from both the academic and non-academic sectors under the theme “Multi-Stimuli Responsive Molecular Systems and Materials.” The objective of the research programme is to prepare new “smart” molecular systems and materials in a bottom-up approach from low molecular weight building blocks by exploiting dynamic covalent chemistry and supramolecular interactions. Close collaboration between the academic and industrial members in this ETN will ensure immediate commercialisation of any new technology or materials developed by the network. This ETN provides a highly structured and comprehensive training programme in nanotechnology, a subject not specifically taught in many European universities. Early-stage researchers will be recruited and trained so they are equipped with a balance of research-related and transferable skills to enhance their career perspectives in both the academic and non-academic sectors. Thus, the network will produce highly skilled, creative, innovative and entrepreneurial researchers who will contribute to European innovation capacity in nanotechnology.