Productivity, competitiveness, and economic growth stem from innovation and are vital in collaborative research projects. However, given the heterogeneity of economic and industrial frameworks between North/Western Europe and South/Eastern Europe, open calls for European funded research projects often exacerbate the knowledge gap between more and less developed regions. This in turn, limits the economic impact of this funding on areas that often need it the most. Czechia and Slovakia have been growing their gross domestic expenditure on R&D, almost doubling it since 2005. However, this growth does not directly equal innovation, with patent applications per million of the population not reaching 15% of the EU benchmark. The GlaCerHub project will strive to support the virtuous innovation and economic cycle by capitalizing on the present-day competitive advantage of the advanced glass and ceramics industry to create a place-based innovation ecosystem in the border region between South Moravia (Czechia), and Trenčín (Slovakia), a region with long tradition in these areas. The GlaCerHub consortium will create a dynamic, specialist innovation ecosystem for the advanced glass and ceramics sector by stimulating new synergies between industry, academia, government, society and other European innovation Ecosystems. In the long term GlaCerHub will become a self-sustaining entity, supporting the creation, development, piloting and protection of strategic technologies, training of all stakeholders from the quadruple helix, and creating and supporting technology transfer. The long term impact will be to increase: - investment in glass and ceramics R&D - IP protection and patent applications - spin-off creation - intersectoral PhDs (and international PhDs) - licensing transactions - national, regional and European recognition of GlaCerHub as a centre of excellence