Macaronesia is a biogeographical region of five archipelagos in the Atlantic Ocean of which four are inhabited: Azores (Portugal), Canarias (Spain), Madeira (Portugal) and Cape Verde (Cabo Verde). These islands share common geographical traits and similar challenges with regards to climate change, environmental degradation and loss of biodiversity. The Canary Islands, Madeira and the Azores are part of the European Union (EU Outermost Regions). The overall objective of this project is to organise a shared Researchers' Night for the Macaronesia Region for the fifth and sixth consecutive year connecting the population of these remote islands under the umbrella of the universal language of science. For these two new editions, MACARONIGHT IV aims at further widening public awareness towards science, research and innovation, especially in areas where the Region faces global challenges, such as those identified in the Horizon Europe Missions. The aim is to reach out to the population in general yet keeping specific focus on teenagers and young parents with kids in particular. The project will deploy an enhanced social-media strategy that aims to engage with citizens of different ages in their own words through their daily used channels. Activities will cover 16 islands with the "main" activities organised at 4 locations: Tenerife (La Laguna), Gran Canaria (Las Palmas), Madeira (Funchal), Azores (Ponta Delgada). The programmes will be organised as "hybrid" online/physical events that will attract 20 thousand participants in 2022 and 25 thousand participants in 2023.