The aim of the MSCAdvocacy project is to provide direct support to better align MSCA cooperation mechanisms of 20 key partner countries and 6 regions with the European Commission’s Global Approach to Research and Innovation. The project will become the strategic link between 1) the European Union’s external policy objectives, 2) bilateral and bi-regional S&T agreements with key partner countries and regions, 3) the corresponding R&I cooperation roadmaps and action plans, and 4) MSCA promotion in the field. With MSCA being the central international component of Horizon Europe (HE), its researcher mobility programmes directly contribute to the objective of the EC’s Global Approach such as strengthening commitment to international openness and fundamental values, rebalancing towards a level playing field and reciprocity, ensuring a free exchange of ideas and fostering research in key areas such as a green transition, the digital transition, global health, and innovation. However, in several key partner countries and regions MSCA do not seem to reach their full strategic potential in line with the objectives mentioned above. Hence, the project will do its part in supporting the strategic alignment of participation and cooperation mechanisms for MSCA to the priorities set on policy level. This will be achieved by 1) reviewing broader policy orientations and monitoring existing cooperation mechanisms with the target countries and regions relevant for MSCA; 2) conducting a Coordination and Support Mission to the targeted countries and regions in order to promote MSCA cooperation opportunities; 3) adressing analyses, reviews, and policy briefs to bilateral and bi-regional R&I policy dialogues; 4) and providing recommendations for long-term strategic promotion in MSCA consistent with EU R&I bilateral and bi-regional cooperation roadmaps and action plans.