The European Industry is currently facing growing number of challenges and the status quo is not acceptable as a sustainable solution. The two main trends of Green and Digital transformation is a strategic call for action for all individual companies, but more and more also between them. The trends of shortening of value chains not only from technological and data-use point of view, but also from de-internationalization perspective became very urgent as recovery measures after the Covid-19 pandemics and will be considered as a potential driver for future resilience building strategies. At the same time, the existing workforce will need to accept and adopt the proposed changes as a new opportunity for sustainable growth, which shall be supported by development of new skills and largely available re-skilling. These and other aspects will be promoted and opinions from industrial leaders collected at the next pan-European conference on Industrial Technologies in Grenoble 2022, France. The feedback will be provided for further policy work on European, national and regional level.