Contributing to the CCRI project portfolio, CisWEFE-NEX will demonstrate the implementation of a circular systemic WEFE Nexus, an innovative, fully integrated, & sustainable approach applying the principles of circular economy for closing loops in the key value chains of food, water & nutrients in severely water stressed regions: 1. Water: - A net positive freshwater balance to the water cycle (JRC 2021) will be achieved through combining olive mill wastewater reuse (as a co-product from biophenols extraction) with saltwater desalination at scale without using fossil fuels for use as drinking & irrigation water. - Waste streams from desalination (brine & bitterns) will be repurposed in nature-based solar saltworks as table & Epsom salt, made possible because of zero chemical use in the desalination process. 2. Energy: - Cutting-edge renewable energy technologies will be developed & demonstrated to achieve a net-zero direct fossil GHG emissions process. - Agri-photovoltaics (crops under PV panels) and biogas from advanced (ultrasonic cavitation assisted) anaerobic digestion fed from olive mill & other biowastes. 3. Food: - Innovative nature-based techniques will be demonstrated to enable truly sustainable, healthy, and fresh food & seaweed (containing bioactive compounds for pharma use) production at scale. - Saltwater integrated multi-trophic aquaculture (free of growth hormones, antibiotics, synthetic fertilisers, & preservatives). - Regenerative agriculture (organic permaculture reusing precious water & nutrients) and extractive reuse of biophenols from olive mill waste as bioactive products of very high nutri-pharmaceutical value. 4. Ecosystems: - Monitoring of traditional & emerging (micro)pollutants using cutting-edge analytics will prevent harmful impacts on the environment & food grown from it with predictive alerts & remedies through a mobile controlled cavitation unit providing (waste)water treatment services (advanced oxidation processes, disinfection).