Superconducting devices based on Josephson Junctions (JJs) are among the most versatile devices in superconducting electronics. Yet challenges remain because conventional JJs are created using a variety of materials that have been identified as a source of noise, dissipation and dephasing, and also, that raise compatibility problems during the fabrication process. FantastiCOF aims at developing a disruptive methodology to prepare exotic highly crystalline superconducting moiré materials, which will exceed the current challenges and limitations of existing materials and methods. Achieving this would represent an important step forward in the fabrication of low-noise JJ devices that will accelerate the development of the next generation of superconducting electronic devices with enhanced performance and sensitivity. FantastiCOF is an archetype of a perfectly balanced high risk/high gain project. It proposes visionary research to tackle the challenges in the synthesis of moiré materials and in the fabrication of low-noise JJs (ambitious and beyond the state-of-the-art), through the development of novel synthetic concepts (bottom-up) and the use of materials (2D covalent organic frameworks) with no precedents in the field, opening the door to a totally unexplored terrain (high risk), but providing tangible pathways towards achievements (solid risk assessment). The inherent high-risk is countered by a strongly interdisciplinary research team composed of 6 partners (5 academics + 1 SME) with different yet highly complementary backgrounds and demonstrated experience in their corresponding fields. Furthermore, FantastiCOF will have a high impact on a broad range of existing and emerging technologies that employ JJs (high gain), such as metrology, medicine, and quantum information technologies.