The GuardIAS project is an ambitious initiative aimed at transforming aquatic environment governance and management in Europe. Its primary goal is to align with the EU Biodiversity Strategy for 2030 and the IAS Regulation, focusing on mitigating the impacts of invasive alien species (IAS) on biodiversity, ecosystem services, and human health. GuardIAS plans to utilize advanced science, technology, and artificial intelligence to develop innovative tools and methodologies. These tools will be instrumental in preventing, detecting, eradicating, and managing IAS. The project is set to advance through interdisciplinary collaboration, integrating data from various sources to create comprehensive IAS impact profiles and management strategies. A significant aspect of GuardIAS is stakeholder engagement and societal involvement. This will be achieved through Citizen Science initiatives and innovative engagement strategies (such as serious games and BioArtBlitz events), aiming to involve the wider community in addressing IAS challenges. GuardIAS will also establish robust solutions for IAS management at multiple governance levels, from local to international. The project will include the development of beyond-the-state-of-the-art technologies and methodologies, such as nano-coatings for marine vessels to prevent IAS spread and eDNA approaches for efficient detection. Additionally, GuardIAS will conduct macroecological and biogeographic analyses to assess IAS risks under various future scenarios, including climate change. The project's comprehensive approach, encompassing science, technology, and community engagement, positions it as a key player in the EU's efforts to preserve biodiversity and protect ecosystems from the growing threat of invasive species. GuardIAS is not only a response to current environmental challenges but also a proactive step towards sustainable management and conservation of aquatic environments in Europe.