The BridgeTTe project has been designed to overcome the most critical gaps in the European innovation landscape between academia and industry that prevent them to benefit from an efficient mutual exchange and use the potential and resources. In particular, the project will address low engagement among the innovation ecosystem actors, missing entrepreneurial competences at academia and insufficient prioritisation of research topics / their links to market / enterprise / industrial needs and are slowly able to react to trends, to name some of the problems addressed. The BridgeTTe project will do so by systemic search for local talents, strategically deploying advanced AI tools, pioneering one-of-its-kind university prototyping programs and market validation assistance, capacity-building training programme and implementing joint activities with business experts, industry clusters and excellent infrastructures from innovation hubs. BridgeTTe will maximise the value of innovation to all by fostering synergies and connectivity of two prominent Central European academic institutions, the Brno University of Technology (BUT) and Slovak University of Technology in Bratislava (STU) to the local, European and global markets by leveraging strategic cooperation with innovation catalysts connected to enterprises (JIC and ADDSEN) and outreach to leading innovation ecosystems and infrastructures (WONDER). BridgeTTe will empower sciencepreneurs, foremostly women, to transform local cutting-edge research into deep-tech start-ups and spin-offs with pan-European and global impact. Through establishing strategic cooperation networks between academia and enterprises, it will nurture the next generation of deep-tech start-ups and spin-offs. The methodology of BridgeTTe connected ecosystems will be further disseminated across the EU and serve as an example worth following, foremostly in emerging innovation ecosystems of the CEE.