Although sugars play a crucial role in many biological processes, their uses in therapeutics remain limited due to their low stability. That’s why organic chemists are constantly pushed to develop new access to original analogues. In particular, replacement of natural anomeric link by C-C mimics (C-glycosides) is widely explored due to their higher chemical and enzymatic stability as well as their conformational similarity compared to natural C-O and C-N analogues. These specific aspects have made these structures potentially valuable enzyme inhibitors. Current synthetic routes of C-glycosides involve several steps and use frequently strong bases, which narrow their development. This last decade, access to complex molecules via C-H functionalization reactions is became very attractive since this strategy avoid to go through pre-functionalized intermediates. In order to circle regioselectivity issues inherent to these transformations, the uses of directing group is commonly chosen in C-H functionalization catalyzed by metallic complexes. Despite the interest of this type of reaction, examples of metal-catalyzed C-H functionalization of sugar-type substrates are scarce and involve in the most of the case intramolecular radical processes. In this project, our goal is to develop new general and efficient synthetic routes to C-aryl-glycosides of interest via metal-catalyzed C-H functionalization reaction of the C-H anomeric bond. These structures showed already several interesting biological activities in diabete 2 treatment for example. The challenge associated to this project is to mono-functionalize complex sugar substrates possessing many similar C-H bonds. Our strategy consists in introducing a directing group on the desired starting glycoside. The position of this directing group is crucial and will be soundly chosen. The first part of the project is interested in the synthesis of C-aryl-glycoside carboxamides as N-acetyl-glycoside mimics. These structures will be obtained via a metal-catalyzed C-H functionalization reaction of unsaturated glycal substrates directed by an amido-group in C2 position. This directing group will be previously installed via a pallado-catalyzed aminocarbonylation process recently developed in our laboratory, between a 2-iodoglycal and an amine in presence of « CO » source. The second part of the project tends to develop access to C-aryl-glycosides via a metal-catalyzed functionalization from saturated glycosides. Our strategy consists in introducing a silylated directing group, easily installed on hydroxyl, on the anomeric hemiacetal function. This type of directing group offer the possibility to access to two types of structures: C-glycosides and keto-glycosides, depending on the cleavage method used at the end of the reaction. In a third part, due to environmental concerns which tend to reduce number of synthetic steps in complex molecule synthesis, the development of metal-catalyzed dehydrogenative C-H functionalization reactions will be planned on the same starting substrates envisaged in the two first methodologies. In this last part, the objective is to couple our glycosides with non pre-functionalized aryl partners. Post-functionalization, deprotection of obtained compounds as well as application of the developed methods to the synthesis of molecules of therapeutical interest will be investigated at the end of each part.