Phosphate (Pi), a major cell component, is a strategically important plant resource due to the impending shortage of high-quality sources of this element. Diminishing the use of Pi in crop production requires a better understanding of the factors that stimulate Pi uptake. It has been widely observed that plants exposed to Pi and Zinc (Zn) deficiencies accumulate more Pi than when they are in more Zn-rich soils. Current data suggest that a specific signaling pathway is involved in the crosstalk between Pi and Zn homeostasis. Although some regulators have been identified recently, most of the early players involved in this pathway remain unknown. The PHLOWZ project aims to clarify the early events involved in this crosstalk, using live imaging of changes in Zn and Pi homeostasis and transcriptomics. PHLOWZ will combine these results with the power of GWAS studies and reverse genetics to identify new early players and regulatory nodes of the Zn/Pi pathway. The discovery of these regulators will have great significance for basic research and agronomical applications.