This project is aimed to providing a new tool to chemists in laboratory or industrial production: a highly efficient regio- and / or enantioselective biocatalysed Baeyer-Villiger oxidation in high concentration. In a first step, a set of new enzymes displaying complementary activities will be proposed to face up to the weakness of the current offer of Baeyer-Villigerases (a dozen available enzymes in laboratory and only one commercialised). The genes of putative BVases will be identified in genomic data banks by comparison of sequences then introduced into host microorganism via a high throughput cloning. High and medium throughput screenings intended to report respectively the activity and enantioselectivity profiles of these enzymes will be set up and carried out in order to develop a tool for making easier and faster the choice of the catalyst On the other hand, productivity often reaches limits because of inhibition (or toxicity) phenomena. To move closer to industrial benchmarks, a process based on adsorbent resins will be implemented to increase concentrations. Besides their "green" and sustainable aspect, Baeyer-Villiger biooxidations present an enzymatic version more efficient in terms of enantioselectivity than the chemical version. In order to harness these features, Dynamic Kinetic Resolution (DKR) process associating in situ substrate racemisation simultaneously with microbiological Baeyer-Villiger oxidation (to overcome the maximal 50 % of yield inherent to classic resolutions) will be developed. Various chemical and enzymatic racemisation conditions will be investigated. DKR and resin-based process will be finally brought together in a Dynamic Kinetic Resolution process at High Concentration, which should lead to a significant increase in productivity. The approach proposed in this project will be validated by the industrial scale production of molecules of interest in the field of flavours or synthesis intermediates.