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In the ARCHANE project, we propose to use archaeal model organisms as chassis to study the biochemical properties of eukaryotic signature proteins found in archaea and their impact on cellular physiology. The aim of this project is to experimentally reconstruct the cellular complexification leading to the emergence of the Asgard archaeal ancestor of eukaryotes by successive introduction of functional eukaryote signature proteins from the TACK (Thaumarchaeota–Aigarchaeota–Crenarchaeota–Korarchaeota) superphylum and Asgardarchaeota into cultivable and genetically tractable archaea, an ambitious task never attempted before. This program should shed light on the pathway of eukaryogenesis from an ancestral archaeon towards the increased cellular complexity of Eukaryotes.
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