In the context of the contemporary globalization process, one could hope that growth would lead to reducing spatial inequalities through the integration of peripheral regions to central places’ dynamics. However, a great number of spaces still differ from centers because of bad living conditions of the majority of their population, often aggravated by the violence of clashes between stakeholders, because of the amplitude of spoliations and of environmental damages. These spaces and the conflicts which take place within them sometimes become a threat to the stability of national governments. How to understand the multiplication of such spaces? We consider the study of their functioning as a necessary first step. For this purpose, the center-periphery model can be mobilized, as long as it is revisited. This center-periphery model, such as formalized by A. Reynaud in the 1980’s and based on an analysis of flows asymmetries, has, in the past decades, opened the way for the understanding of the creation and the reproduction of inequalities between spaces. Within this model, the center is being constituted through a historical process where political and economic dominations mutually reinforce each other. The dependent periphery either provides the center with resources, without benefiting in return from flows of goods or capitals, or losses its inhabitants, all processes occurring under an indifference which is even bigger when peripheral spaces are far from the sight of central locations. One of the strengths of this model was to give account of spatial and regional inequalities at various scales, from urban neighborhoods to regions, countries, or continents. In addition, it enabled Reynaud to differentiate types of peripheries according to the nature, to the intensity and to the combining of flows which connected them to the center. Over the last thirty years or so, globalization has made more complex this schematic vision, as it reached all points of the planet, taking them out of their invisibility and bringing to them new investments, new actors and new norms. Our hypothesis is that these new flows lead to a reconfiguration of spatial asymmetries between centers and peripheries and enable the emergence of new types of spaces. A graphical interpretative model which would integrate flows between central and peripheral spaces (such as A. Reynaud’s one), while taking into account their larger diversity, would allow a better comprehension of these spaces’ situations. Their originality, compared to the peripheries described during the 1980’s, leads us to provisionally characterize them as “globalised margins”. We will start our research with a provisional model elaborated from our knowledge about the flows linking margins to centers in a globalized context: the participants to the project will bring in their expertise on the types of flows which they know best. The robustness of the model will be tested by mobilizing and collecting flows related data in territories already studied by project members. Those data will be reassessed through the light of the common methodology and objectives. We will then integrate these data to sources, opening the path for the confrontation of the initial model to the reality of inbound and outbound margins’ flows, in order to adjust and make it better. These results will finally be valorized and disseminated. If the project can be described as fundamental research before all, its conclusions will enable us to provide advices to local and national societies in order to help them understand their regions ‘ new modes of insertion in the globalization. It will as well offer solutions for the conception of new development strategies, based on better theoretically built territorial diagnosis.