Several diseases spread between persons via the interaction of our bare hands with the outside world. Indeed, a large number of pathogens can survive on inert objects and surfaces and be later transferred onto a person hand who will then auto-contaminate herself. High morbidity or high mortality disease transmission through the contact of our hand with contaminated fomites is responsible each year of a large amount of hospitalizations, with a high associated societal and economical cost. At the present time, owing to a lack of appropriate technology, it is impossible to track down the path of a pathogen being deposited onto a fomite and transferred onto our hands with portable, automated equipment. Indeed, portable miniaturized biological sensors available are only able to detect pathogen at relatively high concentrations. Typically, the measurable pathogen concentrations of current portable equipment correspond to the concentration levels one would find inside the body fluids of an already sick person. So there is currently no fast and portable method to detect pathogen presence on field before they have contaminated and multiplied into a person, which limits disease and biological risk surveillance to “detect-to-treat” approaches. This proposal aims at demonstrating the proof-of-concept of an innovative biological detection and identification technology that would allow the sensing of few pathogen units inside of middle-size liquid volume (typically the volume needed to rinse one’s hands). The short term goal is to combine a pathogen pre-concentrator system with an array of MEMS liquid biological sensors to demonstrate sensing of low viral particles concentrations within a short response time. Neither of these approaches has ever been implemented before to the consortium’s best knowledge. As a matter of fact, the challenge is significant to provide a MEMS sensor that at the same time exhibits good mass sensitivity, a large capture area and that has been properly functionalized with high specificity antibodies to avoid at maximum the occurrence of false-positives. Challenges are also numerous to implement a fluidic tool enabling pre-concentration of viral particles at low concentrations within large volumes and record timing. To overcome these challenges with success, a strong consortium has been built between LETI, LI2D and LASS. This team has combined expertise in micro/nano fluidic systems, MEMS/NEMS based biological sensors, biological functionalization protocols and in design and production of highly sensitive and specific monoclonal antibodies towards specific pathogen viral strains. The long term goal of the proposed research is to provide an upper TRL technological unit enabling fast, ultra-sensitive and fully reliable detection method for pathogens. Such a key enabling technology could be applied, as an example to detect pathogen sampled directly from persons’ hands. Being able to detect pathogen on the hand of a still uncontaminated person would unlock many potential applications and will open a new paradigm in epidemiological surveillance.