The fast spread of multi-resistant microorganisms represents a threat to public health that urgently needs new therapeutic approaches less prone to the development of resistant strains. Our objectives are the design, synthesis and in-depth biophysical studies of new antimicrobial peptide-photosensitizer (AMP-PS) conjugates for synergistic and selective inactivation of pathogens. The chosen AMPs will selectively drive the porphyrinic PS inside the bacteria while near IR light excitation will destroy them by creation of reactive oxygen species (ROS), without inducing bacterial resistance or damage to host tissues. This photoinactivation approach provides a promising treatment for chronic skin and periodontal infections. Thus, an AMP-PS hydrogel will be developed for topical applications. A consortium of three partners specialized in peptide and porphyrin synthesis, biophysical and antibacterial studies, and design of biomaterials, will provide the skills and implementation necessary for the success of the project.