Organisms have always been confronted with changes in environmental conditions, either in space or time. However, the number and rate of anthropogenic alterations impose so intense selective pressures that biodiversity is irreversibly impacted. As well, biodiversity monitoring shows that extinction rate due to global change continues to increase. Plasticity and adaptability are key eco-evolutionary processes that could mitigate biodiversity loss in the face of environmental changes. However, few studies have determined how the combined effects of anthropogenic stressors affect the immediate and evolutionary response of organisms. POLLUCLIM aims at experimentally studying a freshwater organism’s response to the combined effects of climate warming and pollution. Using laboratory microcosms of a ciliate, I will first determine the plastic response to warmer and/or polluted environments (4 different pollutants) of a panel of genotypes. I will then study the probability of evolutionary rescue to these stressors, and determine if exposure to a stressful environment influences the evolutionary response to another stressful environment. Finally, I will relate adaptive patterns to genetic backgrounds and mutagenesis effects of stressors. At the end, the project should improve our understanding of tolerance and adaptability patterns to multiple anthropogenic stressors, with access to the underlying molecular mechanisms.