The industrial transformation of olefins by homogeneous catalysis in the “oxo” process leads to multicomponent reaction mixtures. Their current separation by distillation, quite energy consuming, might be replaced in the chemical factory of the future by organic solvent nanofiltration (OSN) cascades with equivalent performances. CYRANO aims at the development of a simulation tool to assist the design of the most relevant cascade architecture to reach a given objective. The approach is universal aiming at secure the industrial scale-up: (i) acquisition of experimental single-stage filtration results to feed the simulation, (ii) systematic design and evaluation of cascades with internal fluid recirculation, (iii) simulation/experiment confrontation with 2 “cascade pilots” at different scales to validate the robustness of the selected approach, (iv) integration of the cascades into the overall process, (v) environmental impact assessment (LCA).