The primary aim of the research program is to develop a general framework to tailor the design of barrier and safe food packaging systems. As the project will reuse a significant amount of data and methods from basic research and previous EU research programs, it is complementary of the EU effort more specifically directed upstream towards chemical companies and regulatory authorities. The paradigm is however changed: i) by integrating the safety of packaging materials as a component of food engineering (i.e. safe by design instead of controlled as safe) and ii) by making it possible to integrate efficiently the risk of the migration of packaging constituents into food within international food safety standards (e.g. recent ISO 22000-2200x standards). In particular, the project will seek methods and tools that facilitate the cooperation between stakeholders (downstream and upstream) and generate auditable requirements. Generated results and methods will be integrated into an open-source client-server platform, so-called SafeFoodPack Design, including: i) safe design methodologies (Failure Mode Effects and Critical Analysis), ii) simulations tools to optimize barrier properties and minimize the risk of migration of packaging constituent during specific conditions of use (product shelf-life, temperature of storage, hot filling, oven heating…), iii) databases (formulation rulebases, physico-chemical data) and iv) traceability management tools. As the platform will rely exclusively on open standards, it will make it possible to integrate it seamlessly within existing tools used in industries and laboratories, and to share common data formats between stakeholders. In particular, the whole approach will contribute to integrate more efficiently cost (mass reduction), environmental constraints (e.g. use of recycled materials, bio-sourced or biodegradable alternative materials), process constraints (hot filling, aseptic treatments...). By its construction, the project, supported by the National thematic network PROPACKFOOD, is representative of the whole French food packaging sector including the leading professional associations of both Food and Packaging Industries, the national reference laboratories supporting the industry or acting as enforcement laboratory and the leading research laboratories in France on the topic. Rapid and efficient dissemination will be managed by creating a pool of companies (external to the project) that will profit along the project of the proposed framework and training sessions. In return, an efficient feedback from end-users is expected as well a significant impact on upstream stakeholders (Chemical Industry, EU regulatory and surveillance authorities). Customer associations will be invited to participate to our debates.