One in two people will be diagnosed with cancer during their lifetime, presenting a significant challenge to the UK goal of "staying healthy for longer". For some cancers, therapeutic innovations have increased survival, but for other cancers, such as brain cancer, outcomes have changed little in 20 years. A topic of increasing interest in the cancer research community is the critical role of metabolism in cancer cell behaviour. The Warburg effect, a metabolic switch from oxidative to glycolytic metabolism in cancer cells, has been documented for over decades, but much remains unknown about the nature and significance of cancer cell metabolism. The intrinsic pyrogenic substances secreted by tumour cells induce distinct hyperthermia in the temperature range of 37 to 42 C. Simultaneously, different parts of the cell can be at different temperatures, with mitochondria more than 10 C above basal temperature. We need to investigate fundamental unknowns about cancer cell metabolism, its role in cancer growth and the potential of targeting more metabolically active regions within cancer for therapy. Significantly, there is increasing awareness that this needs to be done in the context of intact cancer tissue, where the cancer cell interactions with the cellular microenvironment can be observed. Cancer cell-microenvironment interactions influence cancer cell biology and are not effectively modelled using in vitro cancer cell cultures. Crucially, then, cancer cell metabolism must be interrogated in tissue slice culture, and ultimately in rodent models, for which we need innovative technologies as proposed here. For this, it is necessary to have an imaging technique capable of working in three dimensions in thick tissue, and able to provide the temperature distributions in the cancer environment. This can be achieved by using luminescent nanoparticles as probes. Such nanoparticles can be 500 times smaller than a red blood cell, and when they are excited with light of a wavelength ("colour"), they will re-emit light in a different wavelength. The analysis of this re-emitted light can provide information about the temperature of its environment. Importantly, certain wavelengths can propagate longer in tissue without being attenuated, which can be used for obtaining information from inner areas. This will enable the 3D reconstruction of the map of temperatures.

Humankind is on the brink of significant climate change and material resource shortages. We have reached the limits of our traditional 'take-make-dispose' linear economic models in which materials are extracted from the earth to create products which are discarded at the end of their useful lives. To achieve sustainability with our planet we must rethink the way we consume and use resources and seek to decouple economic growth from primary resource consumption and the associated environmental emissions. Circular economy and the widespread deployment of green energy technologies are essential to achieve this. Even renewable energy technologies have an environmental impact associated with production and disposal at end-of-life, and we must seek to minimise these impacts and maximise product take back for reuse, refurbishment, remanufacturing and recycling once these technologies have ceased to be of use. To achieve this requires lifecycle optimisation, which takes account of product design and development of end-of-life processes. Printable photovoltaics (PPV) are a promising green energy technology in their infancy, which makes this the perfect time to carry out this research. Now is the time to develop processes and product designs which enable effective end-of-life treatment for efficient recovery of materials and components with which to manufacture new products, to drive down cost and environmental impacts of these emerging technologies, increasing the productivity of finite resources available to us. This project develops the eco-design of PPV informed by advanced characterisation and engagement with industrial partners and stakeholders at all stages of PV product lifecycles. This combined novel multidisciplinary approach to technical development of emerging technologies, which engages key industry partners and stakeholders in the value chain; and the development of methods, tools and knowledge required for lifecycle optimisation, can hasten commercialisation of PPV technology and accelerate transition towards circular economy for the greater benefit of the economy, environment and society.

In a consortium led by Heriot-Watt with St Andrews, Glasgow, Strathclyde, Edinburgh, Dundee, Huddersfield and NPL, the "EPSRC CDT in Use-Inspired Photonic Sensing and Metrology" responds to the focus area of "Meeting a User-Need and/or Supporting Civic Priorities" and aligns to EPSRC's Frontiers in Engineering & Technology priority and its aim to produce "tools and technologies that form the foundation of future UK prosperity". Our theme recognises the key role that photonic sensing and metrology has in addressing 21st century challenges in transport (LiDAR), energy (wind-turbine monitoring), manufacturing (precision measurement), medicine (disease sensors), agri-food (spectroscopy), security (chemical sensing) and net-zero (hydrocarbon and H2 metrology). Building on the success of our earlier centres, the addition of NPL and Huddersfield to our team reflects their international leadership in optical metrology and creates a consortium whose REF standing, UKRI income and industrial connectivity makes us uniquely able to deliver this CDT. Photonics contributes £15.2bn annually to the UK economy and employs 80,000 people--equal to automotive production and 3x more than pharmaceutical manufacturing. By 2035, more than 60% of the UK economy will rely on photonics to stay competitive. UK companies addressing the photonic sensing and metrology market are therefore vital to our economy but are threatened by a lack of doctoral-level researchers with a breadth of knowledge and understanding of photonic sensing and metrology, coupled with high-level business, management and communication skills. By ensuring a supply of these individuals, our CDT will consolidate the UK industrial knowledge base, driving this high-growth, export-led sector whose products and services have far-reaching impacts on our society. The proposed CDT will train 55 students. These will comprise at least 40 EngD students, characterised by a research project originated by a company and hosted on their site. A complementary stream of up to 15 PhD students will pursue industrially relevant research in university labs, with more flexibility and technical risk than in an EngD project. In preparing this bid, we invited companies to indicate their support, resulting in £5.5M cash commitments for 102 new students, considerably exceeding our target of 55 students, and highlighting industry's appetite for a CDT in photonic sensing and metrology. Our request to EPSRC for £6.13M will support 35 students, with the remaining students funded by industrial (£2.43M) and university (£1.02M) cash contributions, translating to an exceptional 56% cash leverage of studentship costs. The university partners provide 166 named supervisors, giving the flexibility to identify the most appropriate expertise for industry-led EngD projects. These academics' links to >120 named companies also ensure that the networks exist to co-create university-led PhD projects with industry partners. Our team combines established researchers with considerable supervisory experience (>50 full professors) with many dynamic early-career researchers, including a number of prestigious research fellowship holders. A 9-month frontloaded residential phase in St Andrews and Edinburgh will ensure the cohort gels strongly, equipping students with the knowledge and skills they need before starting their research projects. These core taught courses, augmented with electives from the other universities, will total 120 credits and will be supplemented by accredited MBA courses and training in outreach, IP, communication skills, RRI, EDI, sustainability and trusted-research. Collectively, these training episodes will bring students back to Heriot-Watt a few times each year, consolidating their intra- and inter-cohort networks. Governance will follow our current model, with a mixed academic-industry Management Committee and an International Advisory Committee of world-leading experts.

The Scottish Doctoral Training Centre in Condensed Matter Physics, known as the CM-DTC, is an EPSRC-funded Centre for Doctoral Training (CDT) addressing the broad field of Condensed Matter Physics (CMP). CMP is a core discipline that underpins many other areas of science, and is one of the Priority Areas for this CDT call. Renewal funding for the CM-DTC will allow five more annual cohorts of PhD students to be recruited, trained and released onto the market. They will be highly educated professionals with a knowledge of the field, in depth and in breadth, that will equip them for future leadership in a variety of academic and industrial careers. Condensed Matter Physics research impacts on many other fields of science including engineering, biophysics, photonics, chemistry, and materials science. It is a significant engine for innovation and drives new technologies. Recent examples include the use of liquid crystals for displays including flat-screen and 3D television, and the use of solid-state or polymeric LEDs for power-saving high-illumination lighting systems. Future examples may involve harnessing the potential of graphene (the world's thinnest and strongest sheet-like material), or the creation of exotic low-temperature materials whose properties may enable the design of radically new types of (quantum) computer with which to solve some of the hardest problems of mathematics. The UK's continued ability to deliver transformative technologies of this character requires highly trained CMP researchers such as those the Centre will produce. The proposed training approach is built on a strong framework of taught lecture courses, with core components and a wide choice of electives. This spans the first two years so that PhD research begins alongside the coursework from the outset. It is complemented by hands-on training in areas such as computer-intensive physics and instrument building (including workshop skills and 3D printing). Some lecture courses are delivered in residential schools but most are videoconferenced live, using the well-established infrastructure of SUPA (the Scottish Universities Physics Alliance). Students meet face to face frequently, often for more than one day, at cohort-building events that emphasise teamwork in science, outreach, transferable skills and careers training. National demand for our graduates is demonstrated by the large number of companies and organisations who have chosen to be formally affiliated with our CDT as Industrial Associates. The range of sectors spanned by these Associates is notable. Some, such as e2v and Oxford Instruments, are scientific consultancies and manufacturers of scientific equipment, whom one would expect to be among our core stakeholders. Less obviously, the list also represents scientific publishers, software houses, companies small and large from the energy sector, large multinationals such as Solvay-Rhodia and Siemens, and finance and patent law firms. This demonstrates a key attraction of our graduates: their high levels of core skills, and a hands-on approach to problem solving. These impart a discipline-hopping ability which more focussed training for specific sectors can complement, but not replace. This breadth is prized by employers in a fast-changing environment where years of vocational training can sometimes be undermined very rapidly by unexpected innovation in an apparently unrelated sector. As the UK builds its technological future by funding new CDTs across a range of priority areas, it is vital to include some that focus on core discipline skills, specifically Condensed Matter Physics, rather than the interdisciplinary or semi-vocational training that features in many other CDTs. As well as complementing those important activities today, our highly trained PhD graduates will be equipped to lay the foundations for the research fields (and perhaps some of the industrial sectors) of tomorrow.