We will install a 300kV aberration corrected STEM that utilises artificial intelligence (AI) to simultaneously improve the temporal resolution and precision/sensitivity of images while minimizing the deleterious effect of electron beam damage. Uniquely, this microscope goes beyond post-acquisition uses of AI, and integrates transformational advances in data analytics directly into its operating procedures - experiments will be designed by and for AI, rather than by and for a human operator's limited visual acuity and response time. This distributed algorithm approach to experimental design, is accomplished through a compressed sensing (CS) framework that allows measurements to be obtained under extremely low dose and/or dose rate conditions with vastly accelerated frame rates. Optimizing dose / speed / resolution permits diffusion to be imaged on the atomic scale, creating wide-ranging new opportunities to characterise metastable and kinetically controlled materials and processes at the forefront of innovations in energy storage and conversion, and the wide range of novel engineering/medical functionalities created by nanostructures, composites and hybrid materials. The microscope incorporates in-situ gas / liquid / heating / cryo and straining / indentation stages to study the dynamics of synthesis, function, degradation / corrosion and regeneration / recycling on their fundamental length and time scales. It will be housed in the Albert Crewe Centre (ACC), which is a University of Liverpool (UoL) shared research facility (SRF) specialising in new experimental strategies for high-resolution/operando electron microscopy in support of a wide range of academic/industrial user projects. UoL supports all operational costs for the SRFs (service contracts, staff, consumables, etc), meaning that access to the microscope will always be "free at the point of use" for all academic users. This open accessibility is managed through a user-friendly online proposal submission and independent peer review mechanism linked to an adaptable training/booking system, which allows the ACC to provide extensive research opportunities and training activities for all users. In particular, for early career scientists, we commit experimental resources supporting UoL's commitment to the Prosper project for flexible career development and the Research Inclusivity in a Sustainable Environment (RISE) initiative that is creating a research culture maximising inclusivity and diversity synergistically with encouraging creativity and innovation. This new microscope aligns to several priority areas of research into materials, energy and personalised medicine at the UoL, priority research areas of EPSRC and national facilities in electron microscopy, imaging and materials science, and UKRI plans for infrastructure growth (https://www.ukri.org/research/infrastructure/). In addition to supporting extensive research programs at UoL linked to investments in the Materials Innovation factory (MIF), the Stephenson Institute for Renewable Energy (SIRE) and the new Digital Innovation Facility (DIF), this unique and complimentary microscope will be affiliated to and leverage from partnership with the national microscopy facilities at Harwell (ePSIC) and Daresbury (UKSuperSTEM) and the Henry Royce Institute, as well as form extensive research links to the Rosalind Franklin Institute and the Faraday Institution. We have established (and will expand through outreach activities) an extensive network of partners/collaborators from the N8 university group, Johnson Matthey and NSG, the Universities of Swansea, Birmingham, Warwick, Oxford, Cambridge, Loughborough, Edinburgh and Glasgow and Northwest UK area SME's as well as from universities in the USA, Ireland, Germany, Japan, France, Italy, Denmark, India, Singapore, China, South Africa and Spain who will create a dynamic, innovative and collaborative community driving the long-term research impact of this facility.

The theory of plate tectonics revolutionised the Earth sciences and had impacts across society, by providing a framework to understand the motion of Earth's surface. However, plate tectonic theory does not tell us about the processes deeper in the Earth that drive plate motions, nor does it explain some of the most dramatic events in Earth history: the breakup of plates and outpouring of huge volumes of lava. The next required breakthrough is to make this leap, from a 2D description of plates to understanding the truly 4D nature of Earth's interior processes. Motion of the Earth's interior, its circulation, involves both upwelling and downwelling. The upwelling flow in the Earth remains enigmatic, occurring in the present-day as both hot focused plumes, which are only just observable through modern seismic imaging techniques, and a hypothesised diffuse flow, which has evaded detection entirely. A third mode of mantle upwelling is currently dormant, making its mantle flow signature unknown. However, this dormant mode of flow drives massive outpourings of lava, and has been associated with continental breakup and mass extinction events. Our project's overall goal is to constrain how mantle upwellings operate within the Earth. We will investigate how plate tectonics is linked to mantle circulation, by combining the history of plate movements across Earth's surface with observations drawn from across the geosciences, and use these to constrain state-of-the-art 4D computational models of mantle flow. These advances are made possible by recent progress in disciplines from across the Earth sciences, expertise we bring together here in geodynamics, seismology, geomagnetism, geochemistry, petrology, and thermodynamics. We will constrain present mantle flow by gathering new seismic imaging data of the Earth's deep interior. We will constrain past mantle flow using newly collected data on the mantle's composition, past magnetic field, and the history of Earth's surface uplift. We will use these multidisciplinary approaches to generate the most spatially and temporally complete set of observational constraints on mantle circulation yet assembled. These observations will be used to constrain and improve models that calculate mantle circulation in an Earth-like 3D geometry, driven by plate motion histories (mantle circulation models, MCMs). This is a timely development capitalising on the only recently available record of plate motion over 1 billion years of Earth History. The MCMs predict the mantle's temperature, density, and velocity through time, providing a 4D model of the Earth. Uncertain inputs in these models such as mantle viscosity and composition will be investigated within the bounds provided by the project's geochemical and thermodynamic work packages that will develop new models of Earth's high pressure mineralogy and physical properties. We will test the present-day predictions of the MCMs by converting model outputs to predict density and material properties within the Earth, using our developments on mineral physics modelling. With these inputs and constraints, we will create the first accurate computational models of mantle circulation over the last 1 billion years, which will provide dynamical insight into what drives the diversity of upwellings in the Earth. This tightly integrated multidisciplinary project is absolutely essential to achieve the best constrained MCMs and advance our understanding of Earth's interior processes. The result will be a coherent mantle circulation record of one quarter of Earth's history, and a major advance in our understanding of how mantle upwellings have impacted planetary evolution over this period.

The structure of water and in the way it self-assembles and interacts with dissolved solutes and with hydrophobic surfaces continues to be highly topical. Science ranked the study of water among the top 10 breakthroughs in 2004. The formation and structure of solid state hydrates continues to be a topic of major interest to the pharmaceuticals industry. The problem of interpretation of water structure is complicated by its strong dependence on hydrogen atom positions. Hydrogen atoms cannot be located accurately using X-rays. A meaningful discussion of water structure in the solid state and of its interaction with organic solute species, biological or otherwise, must involve location of H atoms using neutron diffraction. The work must also be backed up by appropriate calculations and corresponding systematic database analysis as well as supporting techniques such as solid state NMR spectroscopy, TGA/DSC and vibrational spectroscopy. This project will amass a body of experimental neutron data on water molecules and clusters within crystals and determine the relative hydrogen bonding energies using calculations based on these experimental coordinates. The key question to answer is what effect does water have on itself and its surroundings and how do water-water interactions compete with water-solute (or, in the solid state, hydrate-host) interactions, particularly in 'large systems' in which many water molecules are present. The insights we will gain will help understand physical properties such as solubility, tendency to form hydrates and the tendency of organic comounds, particularly pharmaceuticals, to adopt more than one solid form.

In modern marine environment, 30-50% of nitrogen lost from the ocean is due to anaerobic ammonium oxidation (anammox). This bacterial process removes an important nutrient, nitrogen, from the marine phytoplankton system. Thus, anammox has a direct consequence on global marine primary production, the uptake of carbon dioxide, and the carbon cycle. Anammox bacteria performing this process are only active in low-oxygen to anoxic settings, included oxygen minimum zones (OMZs) in the water column. OMZs are expanding in our current changing climate and it is important to understand how this expansion will affect anammox activity and in turn the carbon cycle. Reconstructing paleoclimate in analogs for modern and future climate allows us to study how future changes will affect elements like the anammox processes. There are several instances in Earth's climate history when expanding OMZ has led to full-scale oceanic anoxia. Anammox bacteria are members of a deep-branching phylum, and the process has been hypothesised to have played an important role in creating and maintaining oceanic anoxia during crucial periods of Earth's history (e.g. Jurassic and Cretaceous Oceanic Anoxic Events (OAEs)). Determining how anammox was involved in these past scenarios will help better predict what likely outcomes we can expect in our future. Organic geochemistry uses molecular fossils, called biomarkers, to study the impact microbial processes have had on the environment. Currently, tracing anammox bacteria using biomarkers is done using ladderane lipids. However, the applicability of a biomarker has temporal limitations. For example, the inability to withstand degradative processes, which occur during and after deposition, restricts how far back in time these biomarkers can be applied. Although ladderane lipids are excellent biomarkers for modern environments, they are highly labile and not well suited for tracing past anammox activity. Thus, in order to clarify the role anammox has played during these past extreme climate events, lipids must first be identified that can be used as biomarkers in more mature sediments. Two distinct lipid classes have shown potential as biomarkers for past anammox, and will be assessed in this project. These lipids will be evaluated and will be implemented to trace anammox in past oceanic settings. The first class (bacteriohopanepolyols, specifically BHT isomer) seem suitable for sediments deposited within the last 50 Ma, and that have not been exposed to thermal stresses after burial. For example, we will apply these biomarkers to a 2 Myr sediment record underlying the Peru OMZ to explore the hypothesis that anammox influences the expansion of OMZs by contributing to nitrogen removal during increased OMZ. The second class (unusual cyclic and branched long-chain alkanes) extends the time window of detection into thermally mature sediments. These biomarkers will be investigated in OAE events to determine how anammox influenced a shift towards nitrogen-fixation being the dominate pathway of nutrient uptake during OAEs. Additionally, these alkanes will be economically benefit project partners in the petroleum industry, where biomarkers for anoxia would indirectly indicate preservation potential of organic matter and petroleum. We will create a simplified method for anammox detection that we will disseminate to other geochemistry laboratories for their studies of the anammox process. Combined, these findings and those specifically from our system studies will help understand past nitrogen cycling by using our established biomarkers to trace past anammox activity. Finally, the results of our studies of paleo-anammox will be incorporated into the biogeochemical model GENIE. This will improve our understanding of the role anammox played in past nitrogen cycling. Subsequently, model results will help to better predict the implications of anammox on future nitrogen and carbon cycling under our changing climate.

Over the last decade, the creative industries have been revolutionised by the Internet and the digital economy. The UK, already punching above its weight in the global cultural market, stands at a pivotal moment where it is well placed to build a cultural, business and regulatory infrastructure in which first movers as significant as Google, Facebook, Amazon or iTunes may emerge and flourish, driving new jobs and industry. However, for some creators and rightsholders the transition from analogue to digital has been as problematic as it has been promising. Cultural heritage institutions are also struggling to capitalise upon new revenue streams that digitisation appears to offer, while maintaining their traditional roles. Policymakers are hampered by a lack of consensus across stakeholders and confused by partisan evidence lacking robust foundations. Research in conjunction with industry is needed to address these problems and provide support for legislators. CREATe will tackle this regulatory and business crisis, helping the UK creative industry and arts sectors survive, grow and become global innovation pioneers, with an ambitious programme of research delivered by an interdisciplinary team (law, business, economics, technology, psychology and cultural analysis) across 7 universities. CREATe aims to act as an honest broker, using open and transparent methods throughout to provide robust evidence for policymakers and legislators which can benefit all stakeholders. CREATe will do this by: - focussing on studying and collaborating with SMEs and individual creators as the incubators of innovation; - identifying "good, bad and emergent business models": which business models can survive the transition to the digital?, which cannot?, and which new models can succeed and scale to drive growth and jobs in the creative economy, as well as supporting the public sector in times of recession?; - examining empirically how far copyright in its current form really does incentivise or reward creative work, especially at the SME/micro level, as well as how far innovation may come from "open" business models and the "informal economy"; - monitoring copyright reform initiatives in Europe, at WIPO and other international fora to assess how they impact on the UK and on our work; - using technology as a solution not a problem: by creating pioneering platforms and tools to aid creators and users, using open standards and released under open licences; - examining how to increase and derive revenues from the user contribution to the creative economy in an era of social media, mash-up, data mining and "prosumers"; - assessing the role of online intermediaries such as ISPs, social networks and mobile operators to see if they encourage or discourage the production and distribution of cultural goods, and what role they should play in enforcing copyright. Given the important governing role of these bodies should they be subject to regulation like public bodies, and if so, how?; - consider throughout this work how the public interest and human rights, such as freedom of expression, privacy, and access to knowledge for the socially or physically excluded, may be affected either positively or negatively by new business models and new ways to enforce copyright. To investigate these issues our work will be arranged into seven themes: SMEs and good, bad and emergent business models; Open business models; Regulation and enforcement; Creators and creative practice; Online intermediaries and physical and virtual platforms; User creation, behaviour and norms; and, Human rights and the public interest. Our deliverables across these themes will be drawn together to inform a Research Blueprint for the UK Creative Economy to be launched in October 2016.