The ADEPTNESS project seeks to implement and investigate a streamlined and automatic workflow that makes methods and tools to be seamlessly used during design phases as well as in operation. We will explore the generation and reuse of test cases and oracles from initial phases of the development, to the system in operation and back to the laboratory for reproduction. Integrated in this workflow, unforeseen situations will also be detected in operation to enhance development models for increasing resilience. We will consider several aspects of uncertainties (such as uncertainties in environment, uncertainty produced due to timing aspects of CPSoS, uncertainty in networks, etc.). Additionally, automatic and synchronized deployment techniques will be investigated to improve the agility of the whole workflow that covers the design-operation continuum.