Cardiff University and Selden Research have a patented novel catalytic method of making long lived reactive oxygen species effective for pathogen kill and surface disinfection. https://patentimages.storage.googleapis.com/12/c4/b7/8f1ef5827dc436/GB2572364A.pdf The method involves passing an environmentally benign solution containing dilute hydrogen peroxide (H2O2) using a spray bottle through a catalyst (a copper salt on alumina matrix) incorporated in the nozzle. We have tested this with a range of microorganisms including Staphylococcus aureus and Candida albicans yeast and have achieved 99.999% reduction in minutes. To date we have not examined virucidal activity but given the effect of our method on other microorganisms we anticipate it will be effective against enveloped viruses. Our work until now focussed on developing the method for the food preparation and agricultural industries and the key point is that no toxic residues remain on the surfaces that are treated, while also offering exceptional kill efficacy and compatibility with the surfaces treated. The research programme will initially test the virucidal activity of our existing formulation on viruses including coronavirus standard test strain as a surrogate for SARS-CoV-2 (COVID-19). We will then aim to modify and simplify the formulation to determine if we can replace hydrogen peroxide by air whilst maintaining the virucidal activity. We will also develop the use of aerosols so that the new method can be used to treat large spaces which could be applied in the disinfection of PPE for reuse or the environmentally non-toxic disinfection of transportation such as the internal spaces of ambulances, buses, trains and planes.

The aim is to exploit a recent discovery concerning the production of a new high activity catalyst for use in the production of formaldehyde from the oxidation of methanol using a novel nanorod catalysts. These new catalysts have been protected by a patent filing. The key feature of these catalysts is that they give higher yields that the current commercial catalysts. Funding is requested to complete patent exemplification and to ensure commercial exploitation can be achieved.

Catalysis is a core area of science that lies at the heart of the chemicals industry - an immensely successful and important part of the overall UK economy, where in recent years the UK output has totalled over £50B annually and is ranked 7th in the world. This position is being maintained in the face of immense competition worldwide. For the UK to sustain its leading position it is essential that innovation in research is maintained, to achieve which the UK Catalysis Hub was established in 2013; and has succeeded over the last four years in bringing together over 40 university groups for innovative and collaborative research programmes in this key area of contemporary science. The success of the Hub can be attributed to its inclusive and open ethos which has resulted in many groups joining its network since its foundation in 2013; to its strong emphasis on collaboration; and to its physical hub on the Harwell campus in close proximity to the Diamond synchrotron, ISIS neutron source and Central Laser Facility, whose successful exploitation for catalytic science has been a major feature of the recent science of the Hub. The next phase of the Catalysis Hub will build on this success and while retaining the key features and structure of the current hub will extend its programmes both nationally and internationally. The core activities to which the present proposal relates include our coordinating activities, comprising our influential and well attended conference, workshop and training programmes, our growing outreach and dissemination work as well as the core management functions. The core catalysis laboratory facilities within the research complex will also be maintained and developed and two key generic scientific and technical developments will be undertaken concerning first sample environment and high throughput capabilities especially relating to facilities experimentation; and secondly to data management and analysis. The core programme will coordinate the scientific themes of the Hub, which in the initial stages of the next phase will comprise: - Optimising, predicting and designing new catalysts - Water - energy nexus - Catalysis for the Circular Economy and Sustainable Manufacturing - Biocatalysis and biotransformations The Hub structure is intrinsically multidisciplinary including extensive input from engineering as well as science disciplines and with strong interaction and cross-fertilisation between the different themes. The thematic structure will allow the Hub to cover the major areas of current catalytic science

The aim is to exploit a recent discovery concerning the production of a new high activity catalyst for use in the production of hydrogen peroxide from the direct reaction between hydrogen and oxygen using novel gold palladium heteropolyacid catalysts. These new catalysts have been protected by a patent filing. The key feature of these catalysts is that they can be used in water as solvent at ambient temperature whereas all previous catalysts require low temperatures and organic solvents. Initial results show the new catalyst is over fifteen times as active as the current equivalent commercial catalyst. Funding is requested to complete patent exemplification and to ensure commercial exploitation can be achieved.

The Cardiff Catalysis Institute, UK Catalysis Hub, Netherlands Centre for Multiscale Catalytic Energy Conversion (MCEC, Utrecht), and the Fritz-Haber-Institute of the Max Planck Society (FHI, Berlin) will use a novel theory-led approach to the design of new trimetallic nanoparticle catalysts. Supported metal nanoparticles have unique and fascinating physical and chemical properties that lead to wide ranging applications. A nanoparticle, by definition, has a diameter in the range one to one hundred nanometres. For such small structures, particularly towards the lower end of the size range, every atom can count as the properties of the nanoparticle can be changed upon the addition or removal of just a few atoms. Thus, properties of metal nanoparticles can be tuned by changing their size (number of atoms), morphology (shape) and composition (atom types and stoichiometry, i.e., including elemental metals, pure compounds, solid solutions, and metal alloys) as well as the choice of the support used as a carrier for the nanoparticle. The constituent atoms of a nanoparticle that are either part of, or are near the surface, can be exposed to light, electrons and X-rays for characterisation, and this is the region where reactions occur. Our lead application will be catalysis, which is a strategic worldwide industry of huge importance to the UK and global economy. Many catalysts comprise supported metal nanoparticles and this is now a rapidly growing field of catalysis. Metallic NPs already have widespread uses e.g., in improving hydrogen fuel cells and biomass reactors for energy generation, and in reducing harmful exhaust pollutants from automobile engines. Many traditional catalysts contain significant amounts of expensive precious metals, the use of which can be dramatically reduced by designing new multi-element nanocatalysts that can be tuned to improve catalytic activity, selectivity, and lifetime, and to reduce process and materials costs. A major global challenge in the field of nanocatalysis is to find a route to design and fabricate nanocatalysts in a rational, reproducible and robust way, thus making them more amenable for commercial applications. Currently, most supported metal nanocatalysts comprise one or at most two metals as alloys, but this project seeks to explore more complex structures using trimetallics as we now have proof-of-concept studies which show that the introduction of just a small amount of a third metal can markedly enhance catalytic performance. We aim to use theory to predict the structures and reactivities of multi-metallic NPs and to validate these numerical simulations by their synthesis and experimental characterisation (e.g., using electron microscopy and X-ray spectroscopy), particularly using in-situ methodologies and catalytic testing on a reaction of immense current importance; namely the hydrogenation of carbon dioxide to produce liquid transportation fuels. The programme is set out so that the experimental validation will provide feedback into the theoretical studies leading to the design of greatly improved catalysts. The use of theory to drive catalyst design is a novel feature of this proposal and we consider that theoretical methods are now sufficiently well developed and tested to be able to ensure theory-led catalyst design can be achieved. To achieve these ambitious aims, we have assembled a team of international experts to tackle this key area who have a track record of successful collaboration. The research centres in this proposal have complementary expertise that will allow for the study of a new class of complex heterogeneous catalysts, namely trimetallic alloys. The award of this Centre-to-Centre grant will place the UK at the forefront of international catalytic research.