BIORIMA stands for Biomaterial Risk Management. BIORIMA aims to develop an integrated risk management (IRM) framework for nano-biomaterials (NBM) used in Advanced Therapeutic Medicinal Products (ATMP) and Medical Devices (MD). The BIORIMA RM framework is a structure upon which the validated tools and methods for materials, exposure, hazard and risk identification/assessment and management are allocated plus a rationale for selecting and using them to manage and reduce the risk for specific NBM used in ATMP and MD. Specifically, the IRM framework will consist of: (i) Risk Management strategies and systems, based on validated methodologies, tools, and guidance, for monitoring and reducing the risks together with methods for evaluating them; (ii) Validated methodologies and tools to identify the potential Exposure and Hazard posed by NBM to humans and the environment; (iii) A strategy for Intelligent Testing (ITS) and Tiered Risk Assessment for NBM used in ATMP and MD. BIORIMA workplan consists of 7 workpackages covering the major themes: Materials, Exposure, Hazard and Risk. BIORIMA will generate methods and tools for these themes for use in risk evaluation and reduction. The BIORIMA toolbox will consist of validated methods/tools for materials synthesis; reference materials bank; methods for human/environment exposure assessment and monitoring; (eco)-toxicology testing protocols; methods for prevention of accidental risks – massive release or explosion – A tiered risk assessment method for humans/environment; An intelligent testing strategy for NBM and risk reduction measures, including the safer-by-design approach. BIORIMA will deliver a web-based Decision Support System to help users, especially SME, evaluate the risk/benefit profile of their NBM products and help to shorten the time to market for NBM products.

SIMPLIFY, the Sonication and Microwave Processing of material Feedstock project, aims at enabling the electrification of the chemical process industry – and in particular the specialty chemicals industries. SIMPLIFY's vision is that of intensified processes, where alternative energy sources enable flexible continuous technologies to achieve localized ultrasound and microwave actuation of multiphase, flow reactors powered by electricity from renewable sources for the purpose of high-value product synthesis. SIMPLIFY has selected three major classes of specialty processes to work on: i. The class of chemical processes involving highly viscous streams, with MW/US-assisted reactive extrusion of polyurethane as representative; ii. The class of chemical processes involving suspensions, in particular those requiring long residence times (up to hours), with US/MW-assisted reactive crystallization of zeolite microparticles in a continuous oscillatory baffle reactor (COBR); iii. The class of chemical processes involving suspensions, in particular those with inherently high reaction rates (residence times of seconds to minutes), with MW/US-assisted reactive crystallization of titania nanoparticle synthesis in a plug flow reactor (PFR). SIMPLIFY advances the technology readiness level (TRL) of flow technology for these multiphase streams involving suspensions or viscous products from TRL4 (technology validation in lab) to TRL6 (industrial demonstration), thus pushing the transition from chemical reactions with poor resource – both material and energy – efficiency and variable product quality to processes with high resource efficiency and excellent, uniform product properties.