FBI fosters education of ESRs on an emerging, multimodal imaging platform and its translation into clinical and biological applications. In FBI, 15 ESRs are trained at world-leading European academic institutions and companies, thus forming strong interdisciplinary relations between industry, technical sciences and clinical end-users. Optical imaging has huge potential to address unmet clinical needs by combining non-invasive and real-time capture of biomedical information; thus enabling earlier onset of treatment, reduced therapy costs, reduced recurrence rates, and improved clinical outcomes. Up to now, optical modalities were applied as standalone techniques each targeting one biomarker. Recently it has been shown that diagnosis is significantly improved by combining different contrast mechanisms simultaneously in a multimodal approach, i.e., staging and grading of lesions is feasible. FBI proposes to combine a selection of modalities depending on the targeted disease. Suspicious lesions are analysed with optical coherence tomography, optoacoustic tomography, multi-photon tomography, and Raman spectroscopy to provide morphological, label-free microangiography, and intrinsic biochemical information, respectively. An important issue is the need for endoscopy: combining said modalities into endoscopes is challenging due to the integration of different imaging concepts, scanning and detection methods, and laser sources. Accordingly, there is a huge need for effectively translating these technical solutions to industry and clinics, which traditionally is restricted by lack of understanding of applications or limited knowledge of new technology. All these barriers are addressed by FBI through research and development of novel photonic components and systems, through educating ESRs in understanding clinical, biological and commercial challenges, and through developing tailored technical solutions and efficient translation of technology within a strong network.

Optical clocks are amazingly stable frequency standards, which would remain accurate to within one second over the age of the universe. Bringing these clocks from the lab to the market offers great opportunities for telecommunications, navigation, sensing, and science, but no commercial optical clock exists. Europe's world leading optical clock technology within academia and national metrology institutes combined with its strong photonics industry, provide us with a golden opportunity to take a leading position in this strategic technology. With AQuRA we want to seize this opportunity and build up a sovereign, efficient industrial capability able to build the world’s most advanced quantum clocks. We will deliver the first industry-built, rugged and transportable optical clock with an accuracy that approaches the best laboratory clocks. Our work is based on the experience that many of us gained by building an optical clock with industry during the Quantum Flagship project iqClock (2018-2022). In AQuRA industry takes the lead and will deliver a 20x more accurate clock in a 3x smaller volume at TRL 7. This will be possible by combining our industry partners’ experience in rugged photonics products with the know-how of our world-leading academic and national metrology institute partners. We will build, strengthen and diversify the European supply chain of optical clock components, filling critical gaps in the supply chain, and thereby establish a sovereign, competitive industry for optical clocks. In particular we will develop the rugged laser sources, miniaturized optical interface circuits, and the atom source needed for an optical clock, all of which will also become products on their own. Partner Menlo Systems will integrate these components with their ultrastable laser system into the AQuRA optical clock. We will accelerate market uptake by demonstrating our clock's usefulness to applications in telecom, geodesy and metrology, and by engaging with end users.