This EPSRC Overseas Travel Grant will start a new international collaboration between the Department of Medical Physics and Bioengineering at the University College London (UCL) and LabTAU of the Institut National de la Santé et de la Recherche Médicale (INSERM; Lyon, France). The collaboration will result in the development of the world's first open-source Matlab toolbox for acquiring three-dimensional (3D) ultrasound images, and the application of this toolbox to two specific problems: validation of numeric models of ultrasound wave propagation through heterogeneous biological tissue, and visualisation of High Intensity Focused Ultrasound (HIFU) lesion formation through ultrasonically-induced Lorentz force measurements.

Transport of all kinds of components within the cell - from vesicles along the cytoskeleton through to transcription factors along DNA - is fundamental to cell function and health. Neurons are particularly susceptible to small changes in vesicle transport, which underlie motor neuron disease and may also contribute to neuronal degeneration seen in Alzheimer's disease and during ageing. Despite experimental facts that intracellular transport is heterogeneous and non-Markovian with subdiffusive and superdiffusive regimes most mathematical models for vesicles trafficking are Markovian and homogeneous. The main challenge for our Manchester interdisciplinary team is to obtain new non-Markovian models of heterogeneous intracellular transport supported by experiments. These models will provide a tool set for analysing transport processes in a much more realistic way, opening the way for greatly improved analysis and ultimately understanding of these highly complex cellular behaviours. This will allow other researchers to formulate and test new hypotheses. In the long term, therefore, non-Markovian models have the potential to lead to insight into neurological diseases, ageing and other processes that involve intracellular transport such as bacterial and viral infection. Such knowledge will be important for developing new treatments. Our project combines three different approaches: mathematical modelling, numerical modelling and experimental validation, which complement each other. This strategy will provide multidisciplinary study of the intracellular transport problem and ensure maximum impact across and within several disciplines. Our project will allow applied mathematicians (PI and RA), cell biologists and biophysicists (Co-Is and Project Partners) to collaborate thus making significant advances in intracellular transport research and support a cross-disciplinary dissemination.

The water sector in the UK has, by many measures, been very successful. In England and Wales, drinking water standards stands at over 99.9%, water pipe leakage is down by a third, sewer flooding reduced by more three quarters in the last 10 years and bathing water standards are at record high levels. This success has been achieved using a 19th century design approach based on the idea of plentiful resources, unrestrained demand and a stable climate. However, a perfect storm of climate change, increasing population, urbanisation, demographic shifts and tighter regulation is brewing! Each one of these challenges is a threat to the water sector and, taken in isolation, existing approaches may be able to cope. Taken together and compounded by the speed, size and uncertainty of change, the system is heading for failure unless something radical is done. The current way of working looks increasingly out of date and out of step with emerging thinking and best practice in some leading nations. This fellowship aims to meet these emerging challenges and global uncertainties head on by developing a new approach to water management in UK cities. The starting point is a new vision that is: Safe & SuRe. In a sense, our existing water systems are all about safety goals: public health, flood management and environmental protection. These are important and still need to be respected, but they are NOT sufficient to rise to the coming challenges. In the new world of rapid and uncertain change, water systems in cities must also be Sustainable and Resilient. Only a 'Safe & SuRe' system can be moulded, adapted and changed to face the emerging threats and resulting impacts. In this fellowship. my vision will be developed, tested and championed into practice over a period of 5 years. It will draw from multi-disciplinary collaboration with leading academics inside and outside the field. A comprehensive, quantitative evaluation framework will be developed to test in detail what options or strategies can contribute towards a Safe & SuRe water future, focussing on the challenges of water scarcity, urban flooding and river pollution. Recommendations and best practice guidance will be developed in conjunction with key stakeholders.

We will launch a new CDT, focused on composite materials and manufacturing, to deliver the next generation of composites research and technology leaders equipped with the skills to make an impact on society. In recent times, composites have been replacing traditional materials, e.g. metals, at an unprecedented rate. Global growth in their use is expected to be rapid (5-10% annually). This growth is being driven by the need to lightweight structures for which 'lighter is better', e.g. aircraft, automotive car bodywork and wind blades; and by the benefits that composites offer to functionalise both materials and structures. The drivers for lightweighting are mainly material cost, fuel efficiency, reducing emissions contributing to climate change, but also for more purely engineering reasons such as improved operational performance and functionality. For example, the UK composites sector has contributed significantly to the Airbus A400M and A350 airframes, which exhibit markedly better performance over their metallic counterparts. Similarly, in the wind energy field, typically, over 90% of a wind turbine blade comprises composites. However, given the trend towards larger rotors, weight and stiffness have become limiting factors, necessitating a greater use of carbon fibre. Advanced composites, and the possibility that they offer to add extra functionality such as shape adaptation, are enablers for lighter, smarter blades, and cheaper more abundant energy. In the automotive sector, given the push for greener cars, the need for high speed, production line-scale, manufacturing approaches will necessitate more understanding of how different materials perform. Given these developments, the UK has invested heavily in supporting the science and technology of composite materials, for instance, through the establishment of the National Composites Centre at the University of Bristol. Further investments are now required to support the skills element of the UK provision towards the composites industry and the challenges it presents. Currently, there is a recognised skills shortage in the UK's technical workforce for composites; the shortage being particularly acute for doctoral skills (30-150/year are needed). New developments within industry, such as robotic manufacture, additive manufacture, sustainability and recycling, and digital manufacturing require training that encompasses engineering as well as the physical sciences. Our CDT will supply a highly skilled workforce and technical leadership to support the industry; specifically, the leadership to bring forth new radical thinking and the innovative mind-set required to future-proof the UK's global competitiveness. The development of future composites, competing with the present resins, fibres and functional properties, as well as alternative materials, will require doctoral students to acquire underpinning knowledge of advanced materials science and engineering, and practical experience of the ensuing composites and structures. These highly skilled doctoral students will not only need to understand technical subjects but should also be able to place acquired knowledge within the context of the modern world. Our CDT will deliver this training, providing core engineering competencies, including the experimental and theoretical elements of composites engineering and science. Core engineering modules will seek to develop the students' understanding of the performance of composite materials, and how that performance might be improved. Alongside core materials, manufacturing and computational analysis training, the CDT will deliver a transferable skills training programme, e.g. communication, leadership, and translational research skills. Collaborating with industrial partners (e.g. Rolls Royce) and world-leading international expertise (e.g. University of Limerick), we will produce an exciting integrated programme enabling our students to become future leaders.

Metallic materials are used in an enormous range of applications, from everyday objects, such as aluminium drinks cans and copper wiring to highly-specialised, advanced applications such as nickel superalloy turbine blades in jet engines and stainless steel nuclear reactor pressure vessels. Despite advances in the understanding of metallic materials and their manufacture, significant challenges remain. Research in advanced metallic systems helps us to understand how the structure of a material and the way it is processed affects its properties and performance. This knowledge is essential for us to develop the materials needed to tackle current challenges in energy, transport and sustainability. We must learn how to use the earth's resources in a sustainable way, finding alternatives for rare but strategically important elements and increasing how much material we recycle and reuse. This will partly be achieved through developing manufacturing and production processes which use less energy and are less wasteful and through improving product designs or developing and improving the materials we use. In order to deliver these new materials and processes, industry requires a lot more specialists who have a thorough understanding of metallic materials science and engineering coupled with the professional and technical leadership skills to apply this expertise. The EPSRC Centre for Doctoral Training in Advanced Metallic Systems will increase the number of metallurgical specialists, currently in short supply, by training high level physical science and engineering graduates in fundamental materials science and engineering in preparation for doctoral level research on challenging metallic material and manufacturing problems. By working collaboratively with industry, while undertaking a comprehensive programme of professional skills training, our graduates will be equipped to be tomorrow's research leaders, knowledge workers and captains of industry.