PNEUMACRIT will provide a revolutionary multi sensor wearable imaging system that will inform lung function diagnosis for infants and children with conditions that can lead to respiratory problems. Although respiratory support, especially mechanical ventilation, can improve their survival, it may also cause severe injury to the vulnerable lungs, resulting in chronic pulmonary morbidity lasting into adulthood. PNEUMACRIT has the potential to provide early detection of respiratory failure in infants, by providing a low-cost monitoring system, which will also facilitate optimisation of the respiratory support. This will provide both immediate benefits and decrease the risk of patients developing long-term respiratory disorders. PNEUMACRIT pursues breakthroughs in analytical measurement, microsystems embedded in flexible printable wearable materials, signal processing, and organic devices, to produce multi-parameter clinical measurements obtained from the data produced from electrical impedance tomography (EIT), Electrocardiogram (ECG) and apnoea monitoring. EIT is a non-radiative, inexpensive technique that uses small electrical currents to produce cross sectional images of the body that can facilitate real time dynamic monitoring of lung aeration, and recent studies have shown that it is effective in monitoring aeration in preterm babies in a clinical setting. However, to maximise its diagnostics potential, this EIT information need to be combined with other non-invasive measures. Advances in electrode technologies within the project will enable multi-site recordings, without the need for physical interconnection and integrated power supplies, opening the door to a new generation of diagnostic wearables. Such monitoring is crucial because each year millions of babies across the world suffer from respiratory failure due to immaturity of the lung or infectious diseases. In addition, standard lung function tests are not suitable for use with babies and young children until they are old enough to actively co-operate with instructions (~age 7 years). Therefore, PNEMACRIT could, in future, provide valuable lung function information to this age group as well.

Chronic wounds are those that fail to heal in an orderly and timely (typically three months) manner. Examples of chronic wounds include diabetic foot ulcers, pressure ulcers and venous leg ulcers. The incidence of chronic wounds is increasing as a result of lifestyle changes and the ageing population. For example, ~552 million people worldwide are estimated to have diabetes mellitus in 2030. Up to an estimated 25% of these patients will develop diabetic foot ulcers in their lifetime; half of these ulcers will be infected and 20% will undergo amputation of their lower limb. The annual economic impact of chronic wounds, which includes nursing time and dressing materials, on the global economy is estimated to be ~£20 billion by 2030. A common practise in wound management is to cover wounds with suitable dressings to facilitate the healing process. Standard dressings, however, do not provide insights into the status of the wound underneath. Thus, dressings are often changed to examine and assess the wound. This in turn hampers the process of normal wound healing and cause stress and pain to patients. The assessment process also consumes a significant amount of nursing time and dressing materials, which contributes to spiralling medical costs in wound care. In addition, current treatment methods do not use physical or chemical feedback to modify or adjust the treatment based on wound's condition, and hence have limited success. It has been proposed to embed sensors in dressings to enable clinicians and nurses to make effective diagnostic and therapeutic wound management decisions without changing wound dressings; therefore improving patient comfort. Existing sensors, however, do not satisfy the operational (e.g. sensitivity, specificity) and physical (e.g. flexibility) characteristics required for embedding them in dressings. This project will develop a sensor system to overcome these limitations. The proposed sensor system will consist of a small laser that will emit light of different colour based on the concentration of a biomarker of interest in the fluid interface at the wound surface. The change in the colour of emitted light will be measured by waving a mobile device (e.g. phone, tablet) over the dressing containing the sensor system. The captured data will be transmitted to healthcare professionals, processed, stored to keep a record of wound history, and used for diagnostics and therapeutics. The proposed project will benefit patients by effective diagnostics and treatment of chronic wounds. The information on wound condition will permit timely identification of hard to heal wounds and will also be used to create a feedback loop for fully optimised treatments tailored to individual patients. For example, the rate of release of anti-inflammatory drugs will be tailored based on wound condition. This is critical in terms of chronic wound management, where it has been shown that the longer the delay in administering appropriate treatment, the more difficult a wound is to heal.

Chronic wounds are those that fail to heal in an orderly and timely (typically three months) manner. Examples of chronic wounds include diabetic foot ulcers, pressure ulcers and venous leg ulcers. The incidence of chronic wounds is increasing as a result of lifestyle changes and the ageing population. For example, ~552 million people worldwide are estimated to have diabetes mellitus in 2030. Up to an estimated 25% of these patients will develop diabetic foot ulcers in their lifetime; half of these ulcers will be infected and 20% will undergo amputation of their lower limb. The annual economic impact of chronic wounds, which includes nursing time and dressing materials, on the global economy is estimated to be ~£20 billion by 2030. A common practise in wound management is to cover wounds with suitable dressings to facilitate the healing process. Standard dressings, however, do not provide insights into the status of the wound underneath. Thus, dressings are often changed to examine and assess the wound. This in turn hampers the process of normal wound healing and cause stress and pain to patients. The assessment process also consumes a significant amount of nursing time and dressing materials, which contributes to spiralling medical costs in wound care. In addition, current treatment methods do not use physical or chemical feedback to modify or adjust the treatment based on wound's condition, and hence have limited success. It has been proposed to embed sensors in dressings to enable clinicians and nurses to make effective diagnostic and therapeutic wound management decisions without changing wound dressings; therefore improving patient comfort. Existing sensors, however, do not satisfy the operational (e.g. sensitivity, specificity) and physical (e.g. flexibility) characteristics required for embedding them in dressings. This project will develop a sensor system to overcome these limitations. The proposed sensor system will consist of a small laser that will emit light of different colour based on the concentration of a biomarker of interest in the fluid interface at the wound surface. The change in the colour of emitted light will be measured by waving a mobile device (e.g. phone, tablet) over the dressing containing the sensor system. The captured data will be transmitted to healthcare professionals, processed, stored to keep a record of wound history, and used for diagnostics and therapeutics. The proposed project will benefit patients by effective diagnostics and treatment of chronic wounds. The information on wound condition will permit timely identification of hard to heal wounds and will also be used to create a feedback loop for fully optimised treatments tailored to individual patients. For example, the rate of release of anti-inflammatory drugs will be tailored based on wound condition. This is critical in terms of chronic wound management, where it has been shown that the longer the delay in administering appropriate treatment, the more difficult a wound is to heal.

The EPSRC Centre for Innovative Manufacturing in Additive Manufacturing will create a sustainable and multidisciplinary body of expertise that will act as a UK and international focus - the 'go to' place for additive manufacturing and its applications. The Centre will undertake a user-defined and user-driven programme of innovative research that underpins Additive Manufacturing as a sustainable and value-adding manufacturing process across multiple industry sectors.Additive Manufacturing (AM) is the direct production of end-use component parts made using additive layer manufacturing technologies. It enables the manufacture of geometrically complex, low to medium volume production components in a range of materials, with little, if any, fixed tooling or manual intervention beyond the initial product design. AM enables a number of value chain configurations, such as personalised component part manufacture but also economic low volume production within high cost base economies. This innovative approach to manufacturing is now being embraced globally across industry sectors from high value aerospace / automotive manufacture to the creative and digital industries. To date AM research has almost exclusively focused upon the production of single material, homogeneous structures (in polymers, metals and ceramics). The EPSRC Centre for Innovative Manufacturing in Additive Manufacturing will move away from single material, 'passive' AM processes and applications that exhibit conventional levels of functionality, toward the challenges of investigating next generation, multi-material active additive manufacturing processes, materials and design systems. This transformative approach is required for the production of the new generation of high-value, multi-functional products demanded by industry. The Centre will initially explore two themes as the centrepieces of a wider research portfolio, supported by a range of platform activities. The first theme takes on the challenge of how to design, integrate and effectively implement multi-material, multi-functional manufacturing systems capable of matching the requirements of industrial end-users for 'ready-assembled' multifunctional devices and structures. Working at the macro level, this will involve the convergence of several approaches to increase embedded value to the product during the manufacturing stage by the direct printing / deposition of electronic / optical tracks potentially on a voxel by voxel basis; the processing and bonding of dissimilar materials that ordinarily require processing at varying temperatures and conditions will be particularly challenging. The second theme will explore the potential for 'scaling down' AM for small, complex components, extending single material AM to the printing of optical / electronic pathways within micro-level products and with a vision to directly print electronics integrally. The platform activities will provide the opportunity to undertake both fundamental and industry driven pilot studies that both feed into and derive from the theme-based research, and grow the capacity and capability of the Centre, creating a truly national UK Centre and Network that maintains the UK at the front of international research and industrial exploitation in Additive Manufacturing.

The EPSRC Centre for Innovative Manufacturing in Additive Manufacturing will create a sustainable and multidisciplinary body of expertise that will act as a UK and international focus - the 'go to' place for additive manufacturing and its applications. The Centre will undertake a user-defined and user-driven programme of innovative research that underpins Additive Manufacturing as a sustainable and value-adding manufacturing process across multiple industry sectors.Additive Manufacturing (AM) is the direct production of end-use component parts made using additive layer manufacturing technologies. It enables the manufacture of geometrically complex, low to medium volume production components in a range of materials, with little, if any, fixed tooling or manual intervention beyond the initial product design. AM enables a number of value chain configurations, such as personalised component part manufacture but also economic low volume production within high cost base economies. This innovative approach to manufacturing is now being embraced globally across industry sectors from high value aerospace / automotive manufacture to the creative and digital industries. To date AM research has almost exclusively focused upon the production of single material, homogeneous structures (in polymers, metals and ceramics). The EPSRC Centre for Innovative Manufacturing in Additive Manufacturing will move away from single material, 'passive' AM processes and applications that exhibit conventional levels of functionality, toward the challenges of investigating next generation, multi-material active additive manufacturing processes, materials and design systems. This transformative approach is required for the production of the new generation of high-value, multi-functional products demanded by industry. The Centre will initially explore two themes as the centrepieces of a wider research portfolio, supported by a range of platform activities. The first theme takes on the challenge of how to design, integrate and effectively implement multi-material, multi-functional manufacturing systems capable of matching the requirements of industrial end-users for 'ready-assembled' multifunctional devices and structures. Working at the macro level, this will involve the convergence of several approaches to increase embedded value to the product during the manufacturing stage by the direct printing / deposition of electronic / optical tracks potentially on a voxel by voxel basis; the processing and bonding of dissimilar materials that ordinarily require processing at varying temperatures and conditions will be particularly challenging. The second theme will explore the potential for 'scaling down' AM for small, complex components, extending single material AM to the printing of optical / electronic pathways within micro-level products and with a vision to directly print electronics integrally. The platform activities will provide the opportunity to undertake both fundamental and industry driven pilot studies that both feed into and derive from the theme-based research, and grow the capacity and capability of the Centre, creating a truly national UK Centre and Network that maintains the UK at the front of international research and industrial exploitation in Additive Manufacturing.