Fish farming in the UK and around the world faces serious economical threats from viruses and bacteria causing outbreaks and loss of valuable livestock. Vaccines and immunostimulants are often administered to fish to prevent these outbreaks. Continuous research is required to verify whether new products are effective. In order to do so, research worldwide is routinely carried out whereby large groups of animals are experimentally infected with a pathogen. The level of mortalities in groups of fish treated with such substances are then compared with a group of untreated fish. Other researchers have focused on understanding how the fish immune system works and how it combats invasion by bacteria and viruses. For this, experiments are undertaken whereby a group of fish is experimentally infected with viral or bacterial pathogens, then at regular intervals, at least 5 fish are killed and analysed. Both methods are very costly in terms of the number of animals used, and we propose to reduce this from the work carried out during this 2 year project. Instead of killing fish at regular intervals, we propose to take small volumes of blood repeatedly during the course of the infection without harming the fish. The number of animals required for this experiment design represents only 20 % of the number of fish required using traditional sampling methods. In addition, following the same fish during the course of the infection will allow a better understanding of the immune response elicited by the fish, and the outcome of this response i.e. death or survival. Part of the project will be dedicated to improving the analysis method. Because only a small volume of blood is repeatedly sampled over the course of the infection, novel methods are required to measure and describe the immune response. Some of the tools to be includes are antibodies, specifically recognise individual immune molecules, information on fish immune genes and the existence of immortal fish cells that can be cultivated in vitro. These methods will be adapted for use with the small volumes of blood collected and will be used to understand which blood cells, and serum molecules are important in combating the pathogen. The relation between the cell types, the molecules involved, the type of pathogen and the final outcome of the infection will be very important in predicting the severity of infection, determining the appropriate immunostimulant to be used and improving existing fish vaccines.

This proposal is for a new EPSRC Centre for Doctoral Training in Wind and Marine Energy Systems and Structures (CDT-WAMSS) which joins together two successful EPSRC CDTs, their industrial partners and strong track records of training more than 130 researchers to date in offshore renewable energy (ORE). The new CDT will create a comprehensive, world-leading centre covering all aspects of wind and marine renewable energy, both above and below the water. It will produce highly skilled industry-ready engineers with multidisciplinary expertise, deep specialist knowledge and a broad understanding of pertinent whole-energy systems. Our graduates will be future leaders in industry and academia world-wide, driving development of the ORE sector, helping to deliver the Government's carbon reduction targets for 2050 and ensuring that the UK remains at the forefront of this vitally important sector. In order to prepare students for the sector in which they will work, CDT-WAMSS will look to the future and focus on areas that will be relevant from 2023 onwards, which are not necessarily the issues of the past and present. For this reason, the scope of CDT-WAMSS will, in addition to in-stilling a solid understanding of wind and marine energy technologies and engineering, have a particular emphasis on: safety and safe systems, emerging advanced power and control technologies, floating substructures, novel foundation and anchoring systems, materials and structural integrity, remote monitoring and inspection including autonomous intervention, all within a cost competitive and environmentally sensitive context. The proposed new EPSRC CDT in Wind and Marine Energy Systems and Structures will provide an unrivalled Offshore Renewable Energy training environment supporting 70 students over five cohorts on a four-year doctorate, with a critical mass of over 100 academic supervisors of internationally recognised research excellence in ORE. The distinct and flexible cohort approach to training, with professional engineering peer-to-peer learning both within and across cohorts, will provide students with opportunities to benefit from such support throughout their doctorate, not just in the first year. An exceptionally strong industrial participation through funding a large number of studentships and provision of advice and contributions to the training programme will ensure that the training and research is relevant and will have a direct impact on the delivery of the UK's carbon reduction targets, allowing the country to retain its world-leading position in this enormously exciting and important sector.

Seabed sediment represents a significant sink for carbon (C) and represents a major natural asset. Bottom-trawl fishing provides a quarter of global seafood but is also the most extensive anthropogenic physical disturbance to sediment C stocks with recent evidence suggesting that seabed disturbance could result in significant greenhouse gas release from the seabed and to the atmosphere. There are major uncertainties in our understanding of the effect of disturbance on seabed C stores and air/sea CO2 fluxes (in both magnitude and direction). Consequently, the impact of seabed disturbances on C are largely unquantified and currently unregulated. This project will determine how the disturbance associated with bottom trawling modifies C storage, cycling and air/sea CO2 fluxes. For the first time, the impact of trawling on sediment-water and air-sea CO2 exchange will be assessed holistically, providing essential guidance on seabed activity management policies that mitigate climate impacts and help achieve net-zero. The project will answer all four questions defined in the Highlight Topic call: How do fishing gear, trawling frequency and the sedimentary environment affect the potential for marine sediments to act as a net source of CO2? How does C resuspended due to trawling modulate seawater chemistry and what is the fate of the resuspended C? How do horizontal and vertical mixing, water column production and respiration affect the potential for trawl-driven biogeochemical change to result in impacts on air-sea exchanges? Will management interventions result in the reduction of C loss and CO2 emissions and recovery of seabed sediment C stocks? The project comprises of 4 integrated work packages (WPs) that directly address these 4 questions. WP1 will characterise sediment pore waters and quantify the stocks of POC and PIC in the sediment and will identify how trawl gears affect the fluxes of C under different environmental settings. WP2 will characterise changes in the water column and suspended C and sediment and establish its fate in the water column after trawl disturbance. WP3 will quantify the exchange of sub-surface trawl plumes with the surface mixed layer and resultant seawater CO2 and air/sea fluxes. WP1-3 will generate novel insights about the mechanisms through which disturbance affects C fluxes and transformations. A focussed campaign of ship-based experiments will be used to inform and improve model assessments. We selected four representative sites that allow understanding of processes in contrasting environmental settings. The 3 integrated WPs will inform and improve models, which will be used to upscale and extend the spatial and temporal assessment of trawling impacts. These spatial assessments will feed into WP4, which will evaluate and identify the most effective seabed C stock management measures in collaboration with stakeholders from policy, fishing industry, eNGOs and green finance. This research will link processes, impact and mitigation of CO2 emissions due to seabed disturbance. The outcomes of the research will inform environmental solutions by avoiding emissions from seabed sediments while maintaining food production, which sits at the centre of the NERC, UKRI, DEFRA and UK strategies for clean growth and achieving net-zero. This project will make a step change in our understanding of how trawling impacts C dynamics in shelf seas and will diminish the risk of under-valuing natural climate regulation by facilitating cost-benefit analysis and risk assessments.

See lead proposal

By 2050 it is estimated that the global population will exceed 9 billion. This is expected to result in a 100% increase in demand for food. The world needs more high-quality protein, produced in a responsible manner. This challenge is addressed by UN Sustainable Development Goals SDG2 (Zero hunger) and SDG12 (Responsible Consumption and Production). Expansion of marine fish aquaculture has been highlighted as a key route to increase food production. It is also an important area for the blue economy with high potential for new jobs and revenue. In the UK, marine aquaculture is worth over £2 billion to the economy, supports 2300 jobs and has ambitions to double production by 2030. But climate change is a threat as fish production is highly sensitive to the environment. Climate change assessments are often only available for large areas, e.g. global or regional, and do not capture the local conditions that influence fish production. They focus on long-term decadal averages which miss the daily environmental variability and multiple stressors that fish experience. Impacts on growth, health and welfare of the farmed fish are determined by these environment-biological complexities at farm level, and are also influenced by production strategies and industry decisions which may be based on social or economic factors. Robust, industry-relevant, climate impact assessment must include the complexities, relationships and trade-offs between different natural processes and human interventions. Thus, a more comprehensive approach which uses systems thinking to capture the interlinking interdisciplinary components is urgently needed. Precision aquaculture, where vast amounts of data are collected and analysed, offers a framework to provide the detail required to understand the complex farm system, evaluate how the environment is changing and assess implications for future production. In this FLF, I will deliver a rigorous scientific framework for assessing impact of climate change on marine aquaculture using systems thinking and precision-based information. I will create an approach which integrates detailed knowledge of what is happening in the complex farm system now, with future projections of climate change and potential stakeholder response. This will involve collecting high resolution data, analysing complex datasets, developing farm-level models, simulating future climate scenarios, and determining the adaptive capacity of the sector. I will work closely with my network of key industry partners, research organisations, regulators and policy makers to maximise translation and transfer of knowledge and approaches to industry and associated stakeholders. Atlantic salmon (Salmo salar) aquaculture in the Northeast Atlantic (Scotland and Norway) is used as a case study. Salmon leads marine fish production, with over 2 million tonnes produced each year, the equivalent of 17.5 billion meals. Norway and Scotland are responsible for 60% of production. The latitudinal range of farms extends across the thermal tolerance of the salmon, from temperate conditions in Scotland and south Norway, to arctic conditions in the north of Norway. This allows assessment of the spatio-temporal heterogeneity of climate change and a thorough analysis of how impact may vary between locations and different responses required. Beyond aquaculture, the positioning of marine fish farms offers an exceptional opportunity to gain deeper insight into the rate, magnitude and variability of climate change in coastal areas. This FLF will deliver vital new knowledge, data and approaches to understand how the environment is changing. This research is highly interdisciplinary, covering aspects of climate, environmental, biological and social science. The innovative techniques and transformative approaches will allow aquaculture to respond to the climate emergency, enhance blue economy opportunities and maximise its contribution to global food security.