WaysTUP! aims to demonstrate the establishment of new value chains for urban biowaste utilisation to produce higher value purpose products (i.e. biobased products, including food and feed ingredients), through a multi-stakeholder approach in line with circular economy. The project will showcase a portfolio of new ‘urban biowaste to biobased products' processes starting from different feedstocks i.e. fish and meat waste, spent coffee grounds, household source separated biowaste, used cooking oils, cellulosic waste derived from municipal wastewater and waste treatment plants and sewage sludge. Pilot demonstration will take place in several European cities i.e. Valencia (Spain), London (UK), Alicante (Spain), Prague (Czech Republic), Athens (Greece), L'Alcúdia (Spain), Terni (Italy) and Crete (Greece). The processes will result in the production of food and feed additives, flavours, insect protein, coffee oil, bioethanol, biosolvents, polyxydroxyalkanoates, ethyl lactate, long chain dicarboxylic acid, bioplastics and biochar. End-product characterisation and safety assessment will be implemented. Life Cycle Assessment of the value chains will be conducted to assess their environmental impact. WaysTUP! will develop and implement a behavioural change approach with citizens and local communities by improving the current perception of citizens and local communities on urban biowaste as a local resource; enhancing the active participation of citizens in the separate collection of urban biowaste; and improving customer acceptance of urban bio-waste derived products. New profitable business models will be developed preparing market entry of the technology solutions demonstrated as well as of the end-products resulting from them. Finally, the project will provide guidance for city managers on adopting new organisational models supporting the valorisation of urban biowaste, as well as evidence-based EU level policy recommendations for decision makers.

Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.

ICHTHYS (OptImization of novel value CHains for fish and seafood by developing an integraTed sustainable approacH for improved qualitY, safety and waSte reduction) will optimize novel value-chains for fish and seafood products for the EU and international markets. It will develop an integrated sustainable approach to improve quality and safety, while reducing product loss in the whole supply chain. ICHTHYS is intersectorial and focuses on two essential parts of the value chain, postharvest processing and packaging, integrating novel modern techniques and molecular biology tools in the evaluation of the quality and safety of fish and shellfish, including their allergenic capacity. The proposal has 13 consortium members from 6 countries that have complementary expertise in food, aquaculture and postharvest processing. New nonthermal processing methods such as high pressure, pulsed electric fields and high-intensity pulsed light will be studied together with active and intelligent packaging and smart labels (Time Temperature Integrators) and biosensors for monitoring safety and shelf life enriched with novel data from "omics" analysis. The implementation of ICHTHYS will offer the industrial partners the opportunity to translate scientific research into well-defined knowledge-based end products and analytical tools. In addition, to the scientific objectives ICHTHYS will provide a platform for efficient dissemination and transfer of knowledge and technology through training and research with complementary measures to engage other stakeholders including citizens. Overall, ICHTHYS aspires to provide cross-cutting intersectorial and interdisciplinary knowledge exchange and training for academics and commercial partners to improve their employability and career prospects. The project will contribute to the knowledge-based economy and society and boost regional and European competitiveness and growth, food exports and job creation.

The deliberate control of complex microbiomes is notoriously difficult and current approaches are often guided by simple trial-and-error. Advances in quantitative analysis modelling and design of these systems are urgently needed to improve the predictability and enable exploitation of the amazing synthesis capacities of microbiomes. The PROMICON project will learn from nature how microbiomes function through development and application of quantitative physiology, imaging, cell sorting machine learning and systems biology. This will be used to steer existing microbiomes towards production and to generate new synthetic microbiomes inspired by nature through an iterative design-build-test-learn cycle. The new consortia will also contain strains developed through systems metabolic engineering and will be used for the production of energy carriers, drop-in chemical feedstocks and advanced biomaterials. PROMICON will advance characterization tools to understand which strains (modules) are needed for a successful microbiome. It will identify the primary producers (farmers), secondary converters (labourers) and essential strains for microbiome stability (balancers). This knowledge will be used to reduce complexity of natural microbiomes for optimized production of phycobilli protein based pigments, exo-polysaccharides (EPS) and poly-hydroxyalkanoates (PHA) in a top-down approach. Secondly, synthetic microbiomes with increasing complexity (bottom-up) will be assembled for the production of butanol, H2 and PHACOS, a functionalized antimicrobial polyester. PROMICON will develop new reactor concepts and downstream processing for microbiomes and conduct early-stage life cycle assessment (LCA) to prepare exploitation. This ground-breaking project will not only inspire completely new production pathways and a paradigm shift from monocultures to mixed cultures in biotechnology, but also has the potential beyond biotechnology to inspire novel treatment options in biomedicine.

PRESERVE aims at boosting the circular use of bio-based packaging. To shift from the current situation (fossil-based, limited recycling), we build on award-winning upcycling strategies from past and on-going projects. We will enhance the performance of primary food packaging via bio-based barrier coatings for bioplastic and paper/board substrates, as well as via eBeam irradiation and microfibrillar-reinforcement. From the biotechnological side, we will leverage the compounding of enzymes in bioplastics to stimulate biodegradation, the enzymatic recovery of functional oligomers and the delamination of multilayer packaging via enzymatic detergents to enable their layer separation and recycling. The processes required to produce at least 10 packaging demonstrators will be upscaled. The enhanced bio-packaging will be validated with different types of food and drinks. Recovered biopolymers will be upcycled in added value applications such as packaging for personal care products and reusable carrier packaging (using textiles and composites). The versatility of our end of life options, materials, flexible and rigid packaging types and compatibility with different processes, ensure that PRESERVE results are relevant to more than 60% of the plastic packaging on the market, which long term substitution potential will be maximised thanks to the participation of several leading companies in the consortium. Our 2030 roadmap will outline the pathways to significantly influence the emergence of bio-based packaging and create jobs and growth in the sector. To widen PRESERVE impact, we will also perform life cycle and safety assessments, user acceptance studies and contribute to standardisation and certification. All in all, by contributing to the EU Plastics Strategy in a circular economy, our PRESERVE circular renewably sourced packaging solutions and derived upcycled applications will not only optimally preserve the food and drink but also our environment and its finite resources