The TERRIFFIC project will deliver a step change in the effectiveness of first responders during the first hours of a Radiological, Nuclear, explosive (RNe) incident. It will lead to reduced response time, less health and safety risks for the response team, and less human intervention in the operation due to higher number of automated processes and extended mobile detection capabilities. TERRIFFIC will enrich the European response to RNe events by a set of modular technology components in a comprehensive system, incl. new detectors, algorithms, drones, robots, dispersion models, information management software and decision support systems. The project will provide detailed information on the applicability of some developments within a chemical and biological (C/B) context. Dedicated Key Performance Indicators will measure the progress towards targeted performance goals, such as significant acceleration of the time to start terrain interventions due more accurate and near-to-real-time estimation of the control and exclusion zones. Advanced mixed reality technology will be leveraged to provide first responders with ad-hoc available and continuously updated information during operations. TERRIFFIC is SME-led and practitioner-driven. Leading edge technologies will be provided by the R&D partners, whereas key innovative components will be developed by SMEs already involved in military or first responder markets taking on the commercialisation of the TERRIFFIC System and its components. The practitioners will be strongly involved throughout the development process, components assessment and technology trialling. The project will leverage results from previous successful FP7 projects, closely cooperate with ENCIRCLE on the CBRN Cluster and market aspects, and with eNOTICE on training and technology testing and assessment. Special attention will be given to standardisation to optimise the integration with future and already applied solutions.