To succeed in the ambitious objective of achieving a climate-neutral EU by 2050 the nano-enabled bio-based materials sector shall respond to some specific risks in the short term. BIONANOPOLYS will address the following risks and challenges in order to strengthen the circularity of nano-enabled bio-based materials in the economy: › Acceptance of new technology by the market. › Seasonal sustainability of feedstocks. › Price competition and market. › Other risks: The existing legislation is costly in particular for small companies. For example, nano-ecotoxicology related to the use of nano-enabled materials in industry and/or food contact. Considering these challenges, BIONONAPOLYS Open Innovation Test Bed will improve technologies, processes, considering different feedstock. BIONANOPOLYS offers: › PILOT LINES: Cutting edge technology upgraded at TRL 7 with the objetive to produce nanoenabled biobased materials with multifunctional properties to be dispersed in cellulose and polymeric matrices assuring the best dispersion and the robustness of the final properties. Developed materials will be validated in application such as packaging, cosmetic, medical, foam, nonwoven, coating, 3D printing, textiles and cellulose-paper. › PRIMARY RAW MATERIALS FROM DIFFERENT FEEDSTOCKS: BIONANOPOLYS will use the most relevant feedstock in Europe to obtain bio-based nano-enabled composites. › HIGH VOLUME APPLICATIONS: BIONANOPOLYS offer solutions for more than the 50% of the applications that are currently using bio-based materials. › COMPLEMENTARY SERVICES: BIONANOPOLYS will offer to the industry a wide variety of services for the market uptake of a new bio-based nano-enabled products, such as safety protocols for bio-based nano-enabled materials, training for staff specialization, standardisation, business modelling, access to follow-on finance or IPR protection as a crucial mean of ensuring the capitalisation on the investments made by our stakeholders and other investors.

The SABYDOMA programme addresses developments in the safety by design (SbD) paradigm by examining four industrial case studies in detail where the TRLs will advance from 4 to 6. Each TRL activity will progress from being lab based at TRL4 to being industry based at TRL6. The TRL4 activity will involve only innovation with regular industrial communication whereas the TRL6 activity will involve industrially located activities with innovation communication. One of the novel themes of this study is to use system control and optimisation theory including the Model Predictive Control (MPC) philosophy to bind the whole subject of SbD from laboratory innovation to the industrial production line and from decision making processes to project governance. An equally important innovative step is the building of high throughput online platforms where nanomaterial (NM) is manufactured and screened at the point of production. The screening signal controls the NM redesign and production in a feedback loop. Screens will involve (a) physiochemical sensing elements (b) in-vitro targets of increasing complexity from the 2D biomembrane to cell-line and more complex cell-line elements; and, (c) multiple in-vitro targets with multiple end-points; developed in current H2020 projects. Two of the industrial studies include composite coating manufacture where the coating’s stability and toxicity will be tested using a flow through microfluidic flow cell system coupled to online screens. This is part of the release and ageing investigations on the NM and NM coatings and the results of these will feed back to the production line design. At every step on the TRL ladder the in-silico modelling will be applied to optimise and redefine the relevant activities. By the same token regulatory and governance principles of SbD will be used to refine the technological development. The final deliverable will be four distinct technologies applying SbD to the four industrial processes respectively.