Co-created and delivered with industry, REWIRE will accelerate the UK's ambition for net zero by transforming the next generation of high voltage electronic devices using wide/ultra-wide bandgap (WBG/UWBG) compound semiconductors. Our application-driven, collaborative research programme and training will advance the next generation of semiconductor power device technologies to commercialisation and enhance the security of the UK's semiconductor supply-chain. Power devices are at the centre of all power electronic systems. WBG/UWBG compound semiconductor devices pave the way for more efficient and compact power electronic systems, reducing energy loss at the power systems level. The UK National Semiconductor Strategy recognises advances in these technologies and the technical skills required for their development and manufacture as essential to supporting the growing net zero economy. REWIRE's philosophy is centred on cycles of use cases co-created with industry and stakeholders, meeting market needs for devices with increased voltage ranges, maturity and reliability. We will develop multiple technologies in parallel from a range of initial TRL to commercialisation. Initial work will focus on three use cases co-developed with industry, for transformative next generation WBG/UWBG semiconductor power electronic devices: (1) Wind energy, HVDC networks (>10 kV) - increased range high voltage devices as the basis for enabling more efficient power conversion and more compact power converters; (2) High temperature applications, device and packaging - greatly expanded application ranges for power electronics; (3) Tools for design, yield and reliability - improving the efficiency of semiconductor device manufacture. These use cases will: improve higher TRL Silicon Carbide (SiC) 1-2kV technology towards higher voltages; advance low TRL devices such as Gallium Oxide (Ga2O3) and Aluminium Gallium Nitride (AlGaN), diamond and cubic Boron Nitride (c-BN) towards demonstration and ultimately commercialisation; and develop novel heterogenous integration techniques, either within a semiconductor chip or within a package, for enhanced functionality. Use cases will have an academic and industry lead, fostering academia-industry co-development across different work packages. These initial, transformative REWIRE technologies will have wide-ranging applications. They will enhance the efficient conversion of electricity to and from High Voltage Direct Current (HVDC) for long-distance transfer, enabling a sustainable national grid with benefits including more reliable and secure communication systems. New technologies will also bring competitive advantage to the UK's strategically important electric vehicle and battery sectors, through optimised efficiency in charging, performance, energy conversion and management. New use cases will be co-developed throughout REWIRE, with our >30 industrial and policy partners who span the full semiconductor device supply chain, to meet stakeholder priorities. Through engagement with suppliers, manufacturers, and policymakers, REWIRE will pioneer advances in semiconductor supply chain management, developing supply chain tools for stakeholders to improve understanding of the dynamics of international trade, potential supply disruptions, and pricing volatilities. These tools and our Supply Chain Resilience Guide will support the commercialisation of technologies from use cases, enabling users to make informed decisions to enhance resilience, sustainability, and inclusion. Equity, Diversity, and Inclusivity (EDI) are integral to REWIRE's ambitions. Through extensive collaboration across the academic and industrial partners, we will build the diverse, skilled workforce needed to accelerate innovation in academia and industry, creating resilient UK businesses and supply chains.

The Sustainable Chemicals and Materials Manufacturing Hub (SCHEMA) will transform current centralised, fossil-based petrochemicals manufacturing into a sustainable, flexible and digital industry; replacing oil and gas with raw materials from wastes, air and water, driving processes with renewable electricity rather than heat and integrating advances in and computation and information technology to design future materials for functionality and sustainability throughout their life cycles. SCHEMA will deliver UK supply chain resilience and manufacturing sector interconnectivity from chemicals to polymers. By exploiting synergies between diverse industry users, SCHEMA empowers high-growth 'downstream' businesses in transport, energy generation/storage, construction, electronics and fast-moving consumer goods to reach net-zero emissions. This vision requires both a critical mass of diverse research expertise and focussed academic-industry collaboration. SCHEMA convenes experts in sustainable chemistry, process engineering, polymer science and digital technologies from the Universities of Oxford, Bath, Cambridge, Cardiff, Liverpool, Centre for Process Innovation, National Composites Centre, 2 Local Enterprise Partnerships, 25 companies and international partners to co-deliver innovative research, commercialisation and manufacturing advances for a net-zero chemical manufacturing future. Led by Prof Charlotte Williams, SCHEMA augments existing Future Manufacturing Hubs by focussing on interconnected, fundamental research to address four inter-connected sustainable chemical manufacturing Grand Challenges: Transform renewable resources & wastes, with renewable power, to chemicals & polymers. Develop innovative manufacturing processes adaptable for future operations. Integrate digital and information technologies to maximise sustainability and resilience. Design products for life-cycle sustainability, i.e. re-manufacturing, recycling and, in some cases, biodegradation to keep sustainable carbon recirculating. SCHEMA will deliver these through five inter-linked research work packages (WPs) across the manufacturing supply chain: Catalysis and Renewable Power: Selective, scalable and efficient methods to transform air (CO2, water, O2) and wastes into chemical intermediates and monomers. Processes must integrate with renewables, exploiting novel electrochemistry and engineering. Digital and Information Technologies: High efficiency manufacturing delivered through innovative chemistry, in situ/operando analyses, computational feedback loops and automation. Polymerizations and Application Development: Transforming 'green' chemical intermediates into sustainable polymers, elastomers, resins and adhesives. Process Chemistry and Engineering: Developing reactor and process engineering, scalable processes and purification designs for sustainable multi-phase manufacturing process chemistry and engineering. Sustainability Assessments: Assessment, benchmarking and standardisation of new manufacturing processes and products using leading sustainability and techno-economic models. Research integrated and prioritised for technical and theoretical breakthroughs. SCHEMA will integrate industry into these five themes via:

Modern society is reliant on chemical synthesis for the discovery, development and generation of a wide range of essential products. These include advanced materials and polymers, bulk fine chemicals and fertilizers, and most importantly products that impact on human health and food security such as medicines, drugs, and agrochemicals. Future developments in these areas are benficial for society as a whole and also for a wide range of UK industries. To date it has been common practice for the chemical industry to recruit synthetic chemists after PhD/postdoctoral training and then augment their synthetic knowledge with specific industrial training. Due to the changing nature of the chemical and pharmaceutical industry it is recognized that synthetic chemists require an early understanding of the major challenges and methodologies of biology and medicine. The concept of our SBM CDT arose from the need to address this skills gap without compromising training in chemical synthesis. We have designed a training programme focused on EPSRC priorities to produce internationally outstanding doctoral scientists fluent in cutting edge synthesis, and its application to problems in biology and medicine. To achieve this, we have formed a genuinely integrated public-private partnership for doctoral training whereby we combine the knowledge and expertise of industrialists into our programme for both training and research. We have forged partnerships with 11 global industrial partners (GSK, UCB, Vertex, Evotec, Eisai, AstraZeneca, Syngenta, Novartis, Takeda, Sumitomo and Pfizer) and a government agency (DSTL), which have offered: (i) financial support (£4.6M cash and £2.4M in-kind); (ii) contributions to taught courses; (iii) research placements; and (iv) management assistance. Our training partners are global leaders in the pharmaceutical and agrochemical industries and are committed to the discovery, development and manufacture of medicines and agrochemicals for the improvement of human health. To fully exploit the opportunities offered by commercial partners, the SBM Centre will adopt an IP-free model to allow completely unfettered exchange of information, know-how and specific expertise between students and supervisors on different projects and across different industrial companies; this would not be possible under existing studentship arrangements. This free exchange of research data and ideas will generate highly trained and well-balanced researchers capable of world-leading research output, and importantly will enable students to benefit from networks between academic and industrial scientists. This will also facilitate interactions between different industrial and government groups, leading to links between pharmaceutical and agrochemical scientists (for example). The one supervisor - one student model, typical of current studentship programmes, is unable to address significant and long-term training and research topics that require a critical mass of multidisciplinary researchers; consequently we propose that substantive research projects will also be cohort-driven. We envisage that this CDT will have a number of training and research foci ('Project Fields') in which synthesis is the unifying core discipline, to enable our public-private partnership to tackle major problems at the chemistry-biology-medicine interface. Our focused research fields are: New Synthetic Methods, 3D Templates for "Lead-Like" Compounds, Functional Probes for Epigenetics, Next Generation Anti-Infectives, Natural Product Chemistry and Tools for Neuroscience. This doctoral training programme will employ a uniquely integrated academic-industrial training model, producing graduates capable of addressing major challenges in the pharmaceutical/agrochemical industries who will ultimately make a major impact on UK science.