Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreatic neoplasms in a well-defined clinical context, performing simultaneous analysis of genomic and protein markers with a minimal sample volume, reduced costs and reduced time-to-results.

RoLA–FLEX is an industry driven project which provides innovative solutions to the existing OLAE challenges associated with performance and lifetime, through: (a) the fabrication and upscaling of organic semiconductors with high charge mobilities (up to 10 cm2/Vs) and high power conversion efficiencies (16% in OPV cell and 12% in OPV module); (b) the development of metal oxides for charge carrier selective contacts and metal nanoinks for highly conductive micropatterns with increased environmental stability; (c) the seamless incorporation of high speed laser digital processing in Roll-2-Roll OPV module fabrication and photolithography based OTFT manufacturing and (d) the demonstration of two TRL5+ OLAE prototypes enabled by the developed materials and innovative processes: 1. A smart energy platform for IoT devices powered by ITO-free and flexible OPVs operating at low indoor light conditions. 2. A new generation of bezel-less and fully bendable smart watches integrating FHD, ultra-bright OLCD/OTFT displays. RoLA-FLEX will advance all the aforementioned technologies to at least TRL5 within its timeframe. RoLA-FLEX will create an opportunity for a yearly increase in revenues of almost €400 M only 6 years after its end, accompanied by hundreds of new jobs. A timely investment in the early days of these new markets can ensure significant market share for the SMEs and Industries involved and greatly boost EU’s competitiveness globally.