The technology of Micro/Nano-Electro-Mechanical Systems and Micro-Total-Analysis Systems has developed rapidly in the last decade. These miniaturised systems offer the potential to increase yields significantly in chemical, biological and clinical analyses and will lead to significant reductions in process time and reagent consumption. However, there is a major problem in predicting the performance of devices that depend on manipulating gas flows. The thermodynamic quasi-equilibrium hypothesis, on which the Navier-Stokes equations depend, is inappropriate when the mean free path of the gas molecules is comparable to the characteristic dimension of these micro/nano-systems. This research aims to explore whether a mesoscopic lattice Boltzmann equation (LBE) methodology can be established that can predictively model the non-equilibrium gas dynamics in a system with a characteristic length scale between 0.1-1000 microns, which we refer to as a micro/nano-system in the following sections. We will test our LBE model against published observations in a variety of flow configurations and with experimental data provided by BOC Edwards. If successful, the outcomes of this research would contribute to the development of an efficient simulation capability for gas flows in industrially-relevant micro/nano-system geometries.

The Cranfield IMRC vision is to grow the existing world class research activity through the development and interaction between:Manufacturing Technologies and Product/Service Systems that move UK manufacturing up the value chain to provide high added value manufacturing business opportunities.This research vision builds on the existing strengths and expertise at Cranfield and is complementary to the activities at other IMRCs. It represents a unique combination of manufacturing research skills and resource that will address key aspects of the UK's future manufacturing needs. The research is multi-disciplinary and cross-sectoral and is designed to promote knowledge transfer between sectors. To realise this vision the Cranfield IMRC has two interdependent strategic aims which will be pursued simultaneously:1.To produce world/beating process and product technologies in the areas of precision engineering and materials processing.2.To enable the creation and exploitation of these technologies within the context of service/based competitive strategies.

This proposal is for the renewal of the block grant for the Engineering Innovative Manufacturing Centre at the University of Bath. The Centre is unique in combining a design focus with a strong emphasis on manufacture in a closely integrated group. The context of the Centre's work is:* globally distributed design and manufacture of complex products and processes;* pressure on price, quality and timescale;* the move from test-based (physical prototypes) to simulation-based (virtual prototypes) engineering* the movement towards sustainable engineering practice. * the key importance in engineering of knowledge and information management. The Bath Engineering IMRC's mission is to develop tools, methods and knowledge, underpinned by appropriate theory and fundamental research, to support engineering enterprises in these new circumstances. In particular, the focus of the Centre is on whole life design information and knowledge management, and improving the design of machines, processes and systems.

The Innovative Manufacturing and Construction Research Centre (IMCRC) will undertake a wide variety of work in the Manufacturing, Construction and product design areas. The work will be contained within 5 programmes:1. Transforming Organisations / Providing individuals, organisations, sectors and regions with the dynamic and innovative capability to thrive in a complex and uncertain future2. High Value Assets / Delivering tools, techniques and designs to maximise the through-life value of high capital cost, long life physical assets3. Healthy & Secure Future / Meeting the growing need for products & environments that promote health, safety and security4. Next Generation Technologies / The future materials, processes, production and information systems to deliver products to the customer5. Customised Products / The design and optimisation techniques to deliver customer specific products.Academics within the Loughborough IMCRC have an internationally leading track record in these areas and a history of strong collaborations to gear IMCRC capabilities with the complementary strengths of external groups.Innovative activities are increasingly distributed across the value chain. The impressive scope of the IMCRC helps us mirror this industrial reality, and enhances knowledge transfer. This advantage of the size and diversity of activities within the IMCRC compared with other smaller UK centres gives the Loughborough IMCRC a leading role in this technology and value chain integration area. Loughborough IMCRC as by far the biggest IMRC (in terms of number of academics, researchers and in funding) can take a more holistic approach and has the skills to generate, identify and integrate expertise from elsewhere as required. Therefore, a large proportion of the Centre funding (approximately 50%) will be allocated to Integration projects or Grand Challenges that cover a spectrum of expertise.The Centre covers a wide range of activities from Concept to Creation.The activities of the Centre will take place in collaboration with the world's best researchers in the UK and abroad. The academics within the Centre will be organised into 3 Research Units so that they can be co-ordinated effectively and can cooperate on Programmes.