The FINESSE NanoBio team is proposing a new UK capability in imaging, cross-sectioning and patterning materials that are traditionally very difficult to examine at the nano and sub-nanometre scale without seriously effecting their structure or behaviour. It is important that the UK is placed at the forefront of this research, enabling start-ups, SMEs and large companies to drive innovation and growth with stronger underpinning scientific understanding. To address this, the team is requesting funding for a customised Zeiss NanoFab tool that consists of: 1. An ultra-high precision imaging capability (sub 0.5 nm) of conductive and non-conductive samples 2. An ultra-high precision patterning and TEM sample preparation capability (2 nm) of the same range of samples 3. A cryogenic sample handling system to enable imaging of biological materials and biological or fluid interfaces with materials and structures. The tool achieves this revolutionary performance by focusing a stream of helium ions onto the surface and measuring the subsequently released secondary electrons. Ions can also be used to remove material in their path for patterning or cross-sectioning materials. This system has three ion options, gallium for bulk removal, neon for additional polishing and cutting and helium for very careful polishing. This difference in behaviour is due to the lower mass of the ions. Direct writing of metals in 10nm feature sizes is also feasible with this system, which will enable electrical contacts to be fabricated to advanced functional materials to test, for example, their conductivity or electrochemical behaviour when making sensors. The requested support will have far-reaching impact through the projects and industrial partners of almost 50 research groups actively supporting this proposal in Cambridge, across 10 different Departments and 4 different Schools. This sphere of scientific influence is amplified by the strong support from 5 universities, 2 catapult organisations and 3 industrial network organisations, who represent an estimated 1500 companies. This incredible response by academics and industrial researchers means the facility will also drive new engagement and collaborations between these partiers and will foster collaboration, through for example the planned symposium and engagement events. The commissioning, access, outreach and management will be delivered by a small committee of experienced researchers and microscopy suite managers, with review and guidance from a larger steering group of EPSRC, industrial and academic partners to ensure fair access, an environment that fosters collaborations and postgraduate education.

Analysis and diagnosis, the core elements of sensing, are highlighted by almost every initiative for health, environment, security and quality of life. Sensors have advanced to an extent that they are sought for many applications in manufacturing and detection segments, and their cost advantages have boosted their utility and demand. The pillars of sensor research are in highly diverse fields and traditional single-discipline research is particularly poor at catalysing sensor innovation and application, as these typically fall in the 'discipline gaps'. Furthermore, the underpinning technology is advancing at a phenomenal pace. These developments are creating exciting opportunities, but also enormous challenges to UK academia and industry: Traditional PhD programmes are centred on individuals and focused on narrowly defined problems and do not produce the skills and leadership qualities required to capitalise on future opportunities. Industry complains that skills are waning and sensors are increasingly being treated as 'black boxes' without an understanding of underlying principles. We propose to establish the EPSRC Centre for Doctoral Training in Sensor Technologies and Measurement to address these problems head on. The CDT will provide a co-ordinated programme of training in research-, team-, and leadership-skills to future generations of sensor champions. The CDT will build on the highly successful CamBridgeSens research network which was previously funded by the EPSRC under its discipline-bridging programme and which has transformed the culture in which sensor research is being carried out at our University, breaking down discipline barriers, and bringing together world-leading expertise, infrastructure and people from more than 20 Departments. The CDT will now extend this culture to the training of future sensor researchers to generate a virtual super department in Cambridge with more than 70 PIs. The programme will be underpinned by a consortium of industrial partners which is strongly integrated into the CDT and through its needs and engagement will inform the direction of the programme. In the first year of their 4 year PhD programme, student cohorts will attend specialised lectures, practicals and research mini-projects, to receive training in a range of topics underpinning sensor research, including physical principles of sensor hardware, acquisition and interpretation of sensory information, and user requirements of sensor applications. Team-building aspects will be strongly emphasised, and through an extended sensor project treated as a team challenge in the first year of their programme, the students will together, as a cohort, face a problem of industrial relevance and learn how to address a research problem as a team rather than individually. The cohorts will be supported by a mix of academic and industrial mentors, and will receive business, presentation and project-management skills. During years 2 to 4 of their PhD course, students will pick a PhD topic offered by the more than 70 PIs participating in the programme. Each topic on offer will be supervised by at least two academics from different departments/disciplines and may include industrial partners in the CDT. Throughout, we will create strong identities for the sensor student cohorts through a number of people-based activities that maximise engagement between researchers, research activities and that bridge gaps across disciplines, Departments and research cultures.

We propose to build the EPSRC Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future (Sensor CDT) on the foundations we have established with our current CDT (EPSRC CDT for Sensor Technologies and Applications, see http://cdt.sensors.cam.ac.uk). The bid falls squarely into EPSRC's strategic priority theme of New Science and Technology for Sensing, Imaging and Analysis. The sensor market already contributes an annual £6bn in exports to the UK economy, underpinning 73000 jobs and markets estimated at £120bn (source: KTN UK). Major growth is expected in this sector but at the same time there is a growing problem in recruiting suitably qualified candidates with the necessary breadth of skills and leadership qualities to address identified needs from UK industry and to drive sustainable innovation. We have created an integrated programme for high quality research students that treats sensing as an academic discipline in its own right and provides comprehensive training in sensor technologies all the way from the fundamental science of sensing, the networking and interpretation of sensory data, to end user application. In the new, evolved CDT, we will provide training for our CDT students on themes that are of direct relevance to a sustainable and healthy future society, whilst retaining a focus that delivers value to the UK economy and academia. The 4-year programme is strongly cross disciplinary and focuses on sustainable development goals and emphasises training in Responsible Innovation. One example of the latter is our objective to 'democratise sensor technologies': Our students will learn how to engage with the public during research, how to play a valuable part in public debate, and how to innovate technology that benefits society. Technical aspects will be taught in a bespoke training programme for the course, that includes lectures, practicals, lab rotations, industry secondments, and skills training on key underpinning technologies. To support this effort, we have created dedicated, state-of-the-art infrastructure for the CDT that includes laboratory, office, teaching, and social spaces, and we connect to the world leading infrastructure available in the participating departments and partner industries. The programme is designed to create strong identities both within and across CDT cohorts (horizontal and vertical integration) to maximise opportunities for peer-to-peer learning and leadership training through activities such as our unique sensor team challenges and the monthly Sensor Cafés, attended by representatives from academia, industry, government agencies, and the public. We will create a diverse and inclusive atmosphere where students feel confident and empowered to offer different opinions and experiences and which maximises creativity and innovation. We have attracted substantial interest and support (>£2.5M) from established industrial partners, but our new programme emphasises engagement also with UK start-ups and SMEs, who are particularly vulnerable in the current economic climate and who have expressed a need for researchers with the breadth and depth of skills the CDT provides (see letters of support). We recruit outstanding, prizewinning students from a diverse range of disciplines and the training programme connects more than 90 PIs across 15 departments and 40 industrial partners working together to address future societal needs with novel sensor technologies. Technology developers will benefit through connection with experts in middleware (e.g. sensor distribution and networking, data processing) and applications experts (e.g. life scientists, atmospheric scientists, etc.) and vice versa. This integrative character of the CDT will inspire innovations that transform capability in many disciplines of science and industries.

Aerosol science, the study of airborne particles from the nanometre to the millimetre scale, has been increasingly in the public consciousness in recent years, particularly due to the role played by aerosols in the transmission of COVID-19. Vaccines and medications for treating lung and systemic diseases can be delivered by aerosol inhalation, and aerosols are widely used in agricultural and consumer products. Aerosols are a key mediator of poor air quality and respiratory and cardiac health outcomes. Improving human health depends on insights from aerosol science on emission sources and transport, supported by standardised metrology. Similar challenges exist for understanding climate, with aerosol radiative forcing remaining uncertain. Furthermore, aerosol routes to the engineering and manufacture of new materials can provide greener, more sustainable alternatives to conventional approaches and offer routes to new high-performance materials that can sequester carbon dioxide. The physical science underpinning the diverse areas in which aerosols play a role is rarely taught at undergraduate level and the training of postgraduate research students (PGRs) has been fragmentary. This is a consequence of the challenges of fostering the intellectual agility demanded of a multidisciplinary subject in the context of any single academic discipline. To begin to address these challenges, we established the EPSRC Centre for Doctoral Training in Aerosol Science in 2019 (CDT2019). CDT2019 has trained 92 PGRs with 40% undertaking industry co-funded research projects, leveraged £7.9M from partners and universities based on an EPSRC investment of £6.9M, and broadened access to our unique training environment to over 400 partner employees and aligned students. CDT2019 revealed strong industrial and governmental demand for researchers in aerosol science. Our vision for CDT2024 is to deliver a CDT that 'meets user needs' and expands the reach and impact of our training and research in the cross-cutting EPSRC theme of Physical and Mathematical Sciences, specifically in areas where aerosol science is key. The Centre brings together an academic team from the Universities of Bristol (the hub), Bath, Birmingham, Cambridge, Hertfordshire, Manchester, Surrey and Imperial College London spanning science, engineering, medical, and health faculties. We will assemble a multidisciplinary team of supervisors with expertise in chemistry, physics, chemical and mechanical engineering, life and medical sciences, and environmental sciences, providing the broad perspective necessary to equip PGRs to address the challenges in aerosol science that fall at the boundaries between these disciplines. To meet user needs, we will devise and adopt an innovative Open CDT model. We will build on our collaboration of institutions and 80 industrial, public and third sector partners, working with affiliated academics and learned societies to widen global access to our training and catalyse transformative research, establishing the CDT as the leading global centre for excellence in aerosol science. Broadly, we will: (1) Train over 90 PGRs in the physical science of aerosols equipping 5 cohorts of graduates with the professional agility to tackle the technical challenges our partners are addressing; (2) Provide opportunities for Continuing Professional Development for partner employees, including a PhD by work-based, part-time study; (3) Deliver research for end-users through partner-funded PhDs with collaborating academics, accelerating knowledge exchange through PGR placements in partner workplaces; (4) Support the growth of an international network of partners working in aerosol science through focus meetings, conferences and training. Partners and academics will work together to deliver training to our cohorts, including in the areas of responsible innovation, entrepreneurship, policy, regulation, environmental sustainability and equality, diversity and inclusion.

An aerosol consists of solid particles or liquid droplets dispersed in a gas phase with sizes spanning from clusters of molecules (nanometres) to rain droplets (millimetres). Aerosol science is a term used to describe our understanding of the collective underlying physical science governing the properties and transformation of aerosols in a broad range of contexts, extending from drug delivery to the lungs to disease transmission, combustion and energy generation, materials processing, environmental science, and the delivery of agricultural and consumer products. Despite the commonality in the physical science core to all of these sectors, doctoral training in aerosol science has been focussed in specific contexts such as inhalation, the environment and materials. Representatives from these diverse sectors have reported that over 90% of their organisations experience difficulty in recruiting to research and technical roles requiring core expertise in aerosol science. Many of these will act as CDT partners and have co-created this bid. We will establish a CDT in Aerosol Science that, for the first time on a global stage, will provide foundational and comprehensive training for doctoral scientists in the core physical science. Not only will this bring coherence to training in aerosol science in the UK, but it will catalyse new collaborations between researchers in different disciplines. Inverting the existing training paradigm will ensure that practitioners of the future have the technical agility and confidence to move between different application contexts, leading to exciting and innovative approaches to address the technological, societal and health challenges in aerosol science. We will assemble a multidisciplinary team of supervisors from the Universities of Bristol, Bath, Cambridge, Hertfordshire, Imperial, Leeds and Manchester, with expertise spanning chemistry, physics, biological sciences, chemical and mechanical engineering, life and medical sciences, pharmacy and pharmacology, and earth and environmental sciences. Such breadth is crucial to provide the broad perspective on aerosol science central to developing researchers able to address the challenges that fall at the boundaries between these disciplines. We will engage with partners from across the industrial, governmental and public sectors, and with the Aerosol Society of the UK and Ireland, to deliver a legacy of training packages and an online training portal for future practitioners. With partners, we have defined the key research competencies in aerosol science necessary for their employees. Partners will provide support through skills-training placements, co-sponsored studentships, and contribution to taught elements. 5 cohorts of 16 doctoral students will follow a period of intensive training in the core concepts of aerosol science with training placements in complementary application areas and with partners. In subsequent years we will continue to build the activity of the cohort through summer schools, workshops and conferences hosted by the Aerosol Society, virtual training and enhanced training activities, and student-led initiatives. The students will acquire a perspective of aerosol science that stretches beyond the artificial boundaries of traditional disciplines, seeing the commonalities in core physical science. A cohort-based approach will provide a national focal point for training, acting as a catalyst to assemble a multi-disciplinary team with the breadth of research activity to provide opportunities for students to undertake research in complementary areas of aerosol science, and a mechanism for delivering the broad academic ingredients necessary for core training in aerosol science. A network of highly-skilled doctoral practitioners in aerosol science will result, capable of addressing the biggest problems and ethical dilemmas of our age, such as healthy ageing, sustainable and safe consumer products, and climate geoengineering.