Multidrug resistance of Mycobacterium tuberculosis is declared a serious global threat by the World Health Organization. Our project aims at developing a comprehensive model of molecular mechanisms responsible for antimicrobial drug resistance of tuberculosis. Isoniazid is the main drug used for TB treatment, because it interacts with the bacterial catalase that leads to the bacterial death. The library of isoniazid resistant strains (over 100 different strains) will be used as experimental basis for building theoretical and computational models of the molecular processes leading to drug resistance of mutated bacteria. The model will be used for suggesting effective treatment targeting these mechanisms and overcoming the resistance. AMR-TB RISE will be used to utilise the expertise of highly specialised research groups of biologists, clinicians, biochemists, physicists, computer engineers, and mathematicians allowing the researches from these groups to work in multiple laboratories of the Consortium all over the world. Particular attention will be given to training the next generation of young researcher and forming tightly interconnected, long term collaboration devoted to solving the pressing global problem of antimicrobial resistance not only in TB, but in a wide spectrum of diseases.

ENODISE is an enabler project aimed at reducing aircraft gaseous and noise emissions by improving the integration of the propulsion system with the airframe. Complex aerodynamic and acoustic engine-airframe interactions are involved, which must be better understood to yield the expected gains. ENODISE will investigate the main propulsion-airframe integration issues at low TRL and build a solid basis of knowledge and methods based on simplified but representative configurations, permitting to assess a variety of integration concepts. ENODISE will investigate the existence of local/global integration optima via an innovative experimental methodology combined with reduced order modelling and machine learning strategies. Selected configurations will be simulated using methods ranging from low-CPU to high-fidelity. The low-CPU techniques will be employed to verify if the experimentally observed optima can be obtained numerically, and the high-fidelity methods will contribute to the detailed investigation of the aeroacoustic mechanisms in addition to permitting a fine-tuning of the low-cost methods. The work being carried out on relatively low-cost generic configurations, this project will permit spanning a broad parameter space and testing optimization-based robust design methods. Finally, if the interactions between the flow and acoustic field of the propulsion system with the airframe can be detrimental to aerodynamic performance or noise, they also offer opportunities to explore novel flow and acoustic control strategies, not yet explored in combination with installation effects. ENODISE will implement advanced materials and shape modifications to mitigate the adverse installation effects observed during the first phase of the project. The last objective of this project is thus the inclusion of innovative flow and acoustic control technologies in the optimization loop in order to derive better integration designs with minimal detrimental installation effects.