The PATIENT research project hypothesizes that time-critical and curative treatment for bladder cancer can be revolutionised by creating implantable microsystems for a world-first in-situ photodynamic therapy (PDT). Through the complex optimisation and integration of photoactive, porous, and high surface area polymers within a wireless implantable microsystem, we aim to deliver in-situ Singlet Oxygen to enhance tumour cell kill either as a monotherapy or in combination with radiotherapy. This revolutionary new technology has the potential to address the unmet clinical needs of Bladder Cancer associated with late detection, limited treatment options, and a high mortality rate. Current clinical utilisation of PDT is impeded by the associated uptake of the photosensitizer in healthy normal tissue leading to toxicity when exposed to light and difficulties in penetrating the light source to deeper photosensitised cancerous tissues to activate the treatment. The wirelessly powered implantable microsystem targets these two primary limitations as it is designed to enable repeated singlet oxygen at the point of clinical interest because of the incorporation of a micro-light-emitting diode (micro-LED). The controlled delivery of singlet oxygen will sensitise malignant cells to radiation, with the microsystem body being used as an implanted marker for radiotherapy alignment. An extension of this creative concept, that exploits smart, functional materials within a nanoengineering hierarchy coupled with advanced wireless design is that functionalised polymer coatings can be used for post-treatment monitoring of precursor detection of cancer reoccurrence. This will provide a curative treatment pathway via a low-cost enabling technology to improve survival rates, reduce patient side-effects, and create a new post-treatment support option for cancer patients. The potential reward of the PATIENT project is that we will create a new cancer treatment that addresses an unmet clinical need, improving the survival rates for bladder cancer patients. The activation of the medical implant via an external excitation system will also positively impact waiting times, which are vital in high consequence medical interventions for cancer patients. The functionalised polymers in the nanoengineered microsystem will provide both ongoing medical treatment and post-treatment care to detect cancer reoccurrence precursors. Beyond cancer treatment, health boards across the UK are under unprecedented pressure, as evident with over 6 million patients on NHS England waiting lists. COVID-19 has exacerbated the challenges facing UK healthcare provision. The foundational learning within this project, could initiate a new generation of cyber-physical medical assistants that utilise implantable microsystems, providing affordable point of care treatment and diagnostics supporting accessibility (equity) in healthcare provision, reduction of escalating NHS costs, supporting workforce resilience due to levels of demand, and creating a responsive capability to the demands of an aging society with growing long-term care requirements.

Currently, only 40% of people who could benefit from Hearing Aids (HAs) have them, and most people who have HA devices don't use them often enough. There is social stigma around using visible HAs ('fear of looking old'), they require a lot of conscious effort to concentrate on different sounds and speakers, and only limited use is made of speech enhancement - making the spoken words (which are often the most important aspect of hearing to people) easier to distinguish. It is not enough just to make everything louder! To transform hearing care by 2050, we aim to completely re-think the way HAs are designed. Our transformative approach - for the first time - draws on the cognitive principles of normal hearing. Listeners naturally combine information from both their ears and eyes: we use our eyes to help us hear. We will create "multi-modal" aids which not only amplify sounds but contextually use simultaneously collected information from a range of sensors to improve speech intelligibility. For example, a large amount of information about the words said by a person is conveyed in visual information, in the movements of the speaker's lips, hand gestures, and similar. This is ignored by current commercial HAs and could be fed into the speech enhancement process. We can also use wearable sensors (embedded within the HA itself) to estimate listening effort and its impact on the person, and use this to tell whether the speech enhancement process is actually helping or not. Creating these multi-modal "audio-visual" HAs raises many formidable technical challenges which need to be tackled holistically. Making use of lip movements traditionally requires a video camera filming the speaker, which introduces privacy questions. We can overcome some of these questions by encrypting the data as soon as it is collected, and we will pioneer new approaches for processing and understanding the video data while it stays encrypted. We aim to never access the raw video data, but still to use it as a useful source of information. To complement this, we will also investigate methods for remote lip reading without using a video feed, instead exploring the use of radio signals for remote monitoring. Adding in these new sensors and the processing that is required to make sense of the data produced will place a significant additional power and miniaturization burden on the HA device. We will need to make our sophisticated visual and sound processing algorithms operate with minimum power and minimum delay, and will achieve this by making dedicated hardware implementations, accelerating the key processing steps. In the long term, we aim for all processing to be done in the HA itself - keeping data local to the person for privacy. In the shorter term, some processing will need to be done in the cloud (as it is too power intensive) and we will create new very low latency (<10ms) interfaces to cloud infrastructure to avoid delays between when a word is "seen" being spoken and when it is heard. We also plan to utilize advances in flexible electronics (e-skin) and antenna design to make the overall unit as small, discreet and usable as possible. Participatory design and co-production with HA manufacturers, clinicians and end-users will be central to all of the above, guiding all of the decisions made in terms of design, prioritisation and form factor. Our strong User Group, which includes Sonova, Nokia/Bell Labs, Deaf Scotland and Action on Hearing Loss will serve to maximise the impact of our ambitious research programme. The outcomes of our work will be fully integrated, software and hardware prototypes, that will be clinically evaluated using listening and intelligibility tests with hearing-impaired volunteers in a range of modern noisy reverberant environments. The success of our ambitious vision will be measured in terms of how the fundamental advancements posited by our demonstrator programme will reshape the HA landscape over the next decade.

The EMERGENCE network aims to create a sustainable eco-system of researchers, businesses, end-users, health and social care commissioners and practitioners, policy makers and regulatory bodies in order to build knowledge and capability needed to enable healthcare robots to support people living with frailty in the community. By adopting a person-centred approach to developing healthcare robotics technology we seek to improve the quality of life and independence of older people at risk of, and living with frailty, whilst helping to contain spiralling care costs. Individuals with frailty have different needs but, commonly, assistance is needed in activities related to mobility, self-care and domestic life, social activities and relationships. Healthcare can be enhanced by supporting people to better self-manage the conditions resulting from frailty, and improving information and data flow between individuals and healthcare practitioners, enabling more timely interventions. Providing cost-effective and high-quality support for an aging population is a high priority issue for the government. The lack of adequate social care provisions in the community and funding cuts have added to the pressures on an already overstretched healthcare system. The gaps in ability to deliver the requisite quality of care, in the face of a shrinking care workforce, have been particularly exposed during the ongoing Covid-19 crisis. Healthcare robots are increasingly recognised as solutions in helping people improve independent living, by having the ability to offer physical assistance as well as supporting complex self-management and healthcare tasks when integrated with patient data. The EMERGENCE network will foster and facilitate innovative research and development of healthcare robotic solutions so that they can be realised as pragmatic and sustainable solutions providing personalised, affordable and inclusive health and social care in the community. We will work with our clinical partners and user groups to translate the current health and social care challenges in assessing, reducing and managing frailty into a set of clear and actionable requirements that will inspire novel research and enable engineers to develop appropriate healthcare robotics solutions. We will also establish best practice guidelines for informing the design and development of healthcare robotics solutions, addressing assessment, reduction and self-management of frailty and end-user interactions for people with age-related sensory, physical and cognitive impairments. This will help the UK develop cross-cutting research capabilities in ethical design, evaluation and production of healthcare robots. To enable the design and evaluation of healthcare robotic solutions we will utilize the consortium's living lab test beds. These include the Assisted Living Studio in the Bristol Robotics Lab covering the South West, the National Robotarium in Edinburgh together with the Health Innovation South East Scotland's Midlothian test bed, the Advanced Wellbeing Research Centre and HomeLab in Sheffield, and the Robot House at the University of Hertfordshire covering the South East. Up to 10 funded feasibility studies will drive co-designed, high quality research that will lead to technologies capable of transforming community health and care. The network will also establish safety and regulatory requirements to ensure that healthcare robotic solutions can be easily deployed and integrated as part of community-based frailty care packages. In addition, we will identify gaps in the skills set of carers and therapists that might prevent them from using robotic solutions effectively and inform the development of training content to address these gaps. This will foster the regulatory, political and commercial environments and the workforce skills needed to make the UK a global leader in the use of robotics to support the government's ageing society grand challenge.

How can we trust autonomous computer-based systems? Autonomous means "independent and having the power to make your own decisions". This proposal tackles the issue of trusting autonomous systems (AS) by building: experience of regulatory structure and practice, notions of cause, responsibility and liability, and tools to create evidence of trustworthiness into modern development practice. Modern development practice includes continuous integration and continuous delivery. These practices allow continuous gathering of operational experience, its amplification through the use of simulators, and the folding of that experience into development decisions. This, combined with notions of anticipatory regulation and incremental trust building form the basis for new practice in the development of autonomous systems where regulation, systems, and evidence of dependable behaviour co-evolve incrementally to support our trust in systems. This proposal is in consortium with a multi-disciplinary team from Edinburgh, Heriot-Watt, Glasgow, KCL, Nottingham and Sussex, bringing together computer science and AI specialists, legal scholars, AI ethicists, as well as experts in science and technology studies and design ethnography. Together, we present a novel software engineering and governance methodology that includes: 1) New frameworks that help bridge gaps between legal and ethical principles (including emerging questions around privacy, fairness, accountability and transparency) and an autonomous systems design process that entails rapid iterations driven by emerging technologies (including, e.g. machine learning in-the-loop decision making systems) 2) New tools for an ecosystem of regulators, developers and trusted third parties to address not only functionality or correctness (the focus of many other Nodes) but also questions of how systems fail, and how one can manage evidence associated with this to facilitate better governance. 3) Evidence base from full-cycle case studies of taking AS through regulatory processes, as experienced by our partners, to facilitate policy discussion regarding reflexive regulation practices.

Robots and autonomous systems (RAS) will revolutionise the world's economy and society for the foreseeable future, working for us, beside us and interacting with us. The UK urgently needs graduates with the technical skills and industry awareness to create an innovation pipeline from academic research to global markets. Key application areas include manufacturing, construction, transport, offshore energy, defence, and health and well-being. The recent Industrial Strategy Review set out four Grand Challenges that address the potential impact of RAS on the economy and society at large. Meeting these challenges requires the next generation of graduates to be trained in key enabling techniques and underpinning theories in RAS and AI and be able to work effectively in cross-disciplinary projects. The proposed overarching theme of the CDT-RAS can be characterised as 'safe interactions'. Firstly, robots must safely interact physically with environments, requiring compliant manipulation, active sensing, world modelling and planning. Secondly, robots must interact safely with people either in face-to-face natural dialogue or through advanced, multimodal interfaces. Thirdly, key to safe interactions is the ability for introspective condition monitoring, prognostics and health management. Finally, success in all these interactions depends on foundational interaction enablers such as techniques for vision and machine learning. The Edinburgh Centre for Robotics (ECR) combines Heriot-Watt University and the University of Edinburgh and has shown to be an effective venue for a CDT. ECR combines internationally leading science with an outstanding track record of exploitation, and world class infrastructure with approximately £100M in investment from government and industry including the National ROBOTARIUM. A critical mass of over 50 experienced supervisors cover the underpinning disciplines crucial to RAS safe interaction. With regards facilities, ECR is transformational in the range of robots and spaces that can be experimentally configured to study both the physical interaction through robot embodiment, as well as, in-field remote operations and human-robot teaming. This, combined with supportive staff and access to Project Partners, provides an integrated capability unique in the world for exploring collaborative interaction between humans, robots and their environments. The reputation of ECR is evidenced by the additional support garnered from 31 industry Project Partners, providing an additional 23 studentships and overall additional support of approximately £11M. The CDT-RAS training programme will align with and further develop the highly successful, well-established CDT-RAS four-year PhD programme, with taught courses on the underpinning theory and state of the art and research training, closely linked to career relevant skills in creativity, RI and innovation. The CDT-RAS will provide cohort-based training with three graduate hallmarks: i) advanced technical training with ii) a foundation international experience, and iii) innovation training. Students will develop an assessed learning portfolio, tailored to individual interests and needs, with access to industry and end-users as required. Recruitment efforts will focus on attracting cohorts of diverse, high calibre students, who have the hunger to learn. The single-city location of Edinburgh enables stimulating, cohort-wide activities that build commercial awareness, cross-disciplinary teamwork, public outreach, and ethical understanding, so that Centre graduates will be equipped to guide and benefit from the disruptions in technology and commerce. Our vision for the CDT-RAS is to build on the current success and ensure the CDT-RAS continues to be a major international force that can make a generational leap in the training of innovation-ready postgraduates, who will lead in the safe deployment of robotic and autonomous systems in the real world.